Journal
MOLECULES
Volume 27, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules27041438
Keywords
antifungal peptides; drug resistance; invasive fungal infections; non-albicans Candida; skin wounds
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Due to high mortality and limited available antifungal drugs, there is a need to develop alternative therapies. This study investigated the effectiveness of four pore-forming antimicrobial peptides against clinically relevant pathogens and assessed their compatibility with human cells. Mastoparan B exhibited strong antifungal activity, while cecropin A was the least potent. These findings are important for the design and development of safe antifungal peptide-based drugs.
The high mortality associated with invasive fungal infections, narrow spectrum of available antifungals, and increasing evolution of antifungal resistance necessitate the development of alternative therapies. Host defense peptides are regarded as the first line of defense against microbial invasion in both vertebrates and invertebrates. In this work, we investigated the effectiveness of four naturally occurring pore-forming antimicrobial peptides (melittin, magainin 2, cecropin A, and mastoparan B) against a panel of clinically relevant pathogens, including Candida albicans, Candida parapsilosis, Candida tropicalis, and Candida glabrata. We present data on the antifungal activities of the four pore-forming peptides, assessed with descriptive statistics, and their cytocompatibility with cultured human cells. Among the four peptides, mastoparan B (MB) displayed potent antifungal activity, whereas cecropin A was the least potent. We show that MB susceptibility of phylogenetically distant non-candida albicans can vary and be described by different intrinsic physicochemical parameters of pore-forming alpha-helical peptides. These findings have potential therapeutic implications for the design and development of safe antifungal peptide-based drugs.
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