Journal
MOLECULES
Volume 27, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules27030789
Keywords
functionalization; magnetite nanoparticles; nanoantioxiants
Funding
- King Khalid University [R.G.P 2/74/41, ST 028-2019, ICF 073-2019]
- University of Malaya, Kuala Lumpur
- [50603]
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In this study, functionalized magnetite nanoparticles were successfully prepared and functionalized with a multipotent antioxidant. The functionalized nanoparticles showed superparamagnetic properties and demonstrated the ability to scavenge free radicals and exhibit antimicrobial properties. These findings suggest that the developed nanoantioxidants have potential applications in biomedicine and nanomedicine.
Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine.
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