Journal
MOLECULES
Volume 27, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules27030584
Keywords
plastic pollution; fishes; oxidative stress; lipid metabolism; energy metabolism
Funding
- National Natural Science Foundation of China [31802023]
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Microplastic exposure caused various sublethal effects on rare minnows, including cellular and tissue alterations in the liver. Transcriptomic and metabolomic analyses revealed significantly varied metabolic pathways, such as glucolipid, amino acid, and nucleotide metabolism. Results showed that microplastic exposure induced immune reaction, oxidative stress, and disturbed glycolipid and energy metabolism in rare minnows.
Microplastics are environmental contaminants and an emergent concern. Microplastics are abundant in freshwater and can cause biochemical stress in freshwater organisms. In the current study, rare minnows (Gobiocypris rarus) were exposed to 1 mu m polystyrene microplastics at 200 mu g/L concentration. We observed various sublethal effects after four weeks of exposure but no mortality. Numerous cellular and tissue alterations were observed in the liver. Differential metabolites and differentially expressed genes between control and exposure groups were identified and mapped to pathways in the Kyoto Encyclopedia of Genes and Genomes. The combination of transcriptomic and metabolomic analyses revealed significantly varied metabolic pathways between the two groups. These pathways were involved in glucolipid, amino acid, and nucleotide metabolism. Results demonstrated that MP exposure induced immune reaction, oxidative stress, and disturbed glycolipid and energy metabolism. The current study provided novel insights into the molecular and metabolic mechanisms of microplastic ecotoxicology in rare minnow.
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