Journal
MOLECULES
Volume 27, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules27030596
Keywords
rectal cancer; apoptosis; proliferation; radiotherapy; Chromogranin A
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This study aims to explore the potential roles of apoptosis markers, proliferation markers, and neuroendocrine markers as indicators for the radioresistance of rectal cancer. The results showed that p53, Ki-67, and Chromogranin A have significant prognostic value for patients after radiotherapy. Additionally, Chromogranin A, as a marker of neuroendocrine differentiation, can predict a poor prognosis.
The aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.
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