4.6 Review

Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension

Xuemei Wang et al.

Summary: Total isoflavones, daidzein, and genistein intake were found to be inversely associated with NAFLD, hyperlipidaemia, and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2022)

Article Nutrition & Dietetics

Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice

Rui Yang et al.

Summary: GEN treatment can improve glucose and lipid metabolism disorders in T2D mice, as well as hepatic and colonic dysfunction; most importantly, GEN can ameliorate inflammation and insulin resistance through modulation of gut microbiota composition.

EUROPEAN JOURNAL OF NUTRITION (2021)

Article Medicine, Research & Experimental

Daidzein ameliorates diabetic retinopathy in experimental animals

Ankit P. Laddha et al.

Summary: The study demonstrated that daidzein has a therapeutic effect on diabetic retinopathy by significantly lowering levels of blood glucose, lactate dehydrogenase, aldose reductase, and sorbitol dehydrogenase, as well as reducing oxidative stress and improving retinal thickness after treatment.

LIFE SCIENCES (2021)

Review Biology

The Vascular Effects of Isolated Isoflavones-A Focus on the Determinants of Blood Pressure Regulation

Henrique Silva

Summary: Isoflavones are natural phytoestrogens found in soybeans and known to improve cardiovascular health, particularly in populations with a high dietary intake. They exert vasorelaxation through various pathways in different vascular beds, enhancing the release of vasorelaxant mediators and leading to relaxation through hyperpolarization. These effects are achieved at micromolar concentrations only attainable through supplementation, highlighting isoflavones as potential alternatives to soy-based products for cardiovascular health improvement.

BIOLOGY-BASEL (2021)

Article Environmental Sciences

Effect of Soybean and Soybean Koji on Obesity and Dyslipidemia in Rats Fed a High-Fat Diet: A Comparative Study

Sihoon Park et al.

Summary: Soybean koji and soybean have different effects on high-fat diet-induced obesity in rats, with soybean koji showing better anti-obesity effects by regulating lipogenesis.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Nutrition & Dietetics

Phytoestrogen blood levels and adverse outcomes in women with suspected ischemic heart disease

Lili Barsky et al.

Summary: The study found that low serum glycitin levels were associated with increased MACE and earlier angina hospitalization in women suspected of ischemic heart disease, while low genistein levels were associated with increased MACE after 6 years. Future studies are needed to examine the relationship between phytoestrogens, nutrition, outcomes, and potential supplementation.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

Review Food Science & Technology

Effects of genistein on blood pressure: A systematic review and meta-analysis

Niloofar Hemati et al.

FOOD RESEARCH INTERNATIONAL (2020)

Article Cardiac & Cardiovascular Systems

Association between coronary atherosclerosis and visceral adiposity index

Zsolt Bagyura et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

Review Biochemistry & Molecular Biology

Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical Implications

Ibrahim Kalle Kwaifa et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent

Yae Rim Choi et al.

MOLECULES (2020)

Article Endocrinology & Metabolism

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects

Martha Guevara-Cruz et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

Review Cardiac & Cardiovascular Systems

Dietary interventions in blood pressure lowering: current evidence in 2020

Larysa Strilchuk et al.

KARDIOLOGIA POLSKA (2020)

Article Biochemistry & Molecular Biology

Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1

Mailin Gan et al.

FOOD & FUNCTION (2020)

Review Cardiac & Cardiovascular Systems

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease

Alan Chait et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

Isoflavones

Ludmila Krizova et al.

MOLECULES (2019)

Article Medicine, Research & Experimental

Genistein enhances the secretion of glucagon-like peptide-1 (GLP-1) via downregulation of inflammatory responses

Kanwal Rehman et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Endocrinology & Metabolism

Type 2 diabetes: a multifaceted disease

Ewan R. Pearson

DIABETOLOGIA (2019)

Article Food Science & Technology

Effect of Genistein on Cholesterol Metabolism-Related Genes in HepG2 Cell

Rongrong Lu et al.

JOURNAL OF FOOD SCIENCE (2019)

Article Endocrinology & Metabolism

Clinical and metabolic response to soy administration in older women with metabolic syndrome: a randomized controlled trial

Afsaneh Bakhtiari et al.

DIABETOLOGY & METABOLIC SYNDROME (2019)

Article Endocrinology & Metabolism

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia

Tao Zhang et al.

DIABETOLOGY & METABOLIC SYNDROME (2019)

Review Biochemistry & Molecular Biology

LOX-1: Regulation, Signaling and Its Role in Atherosclerosis

Ajoe John Kattoor et al.

ANTIOXIDANTS (2019)

Article Nutrition & Dietetics

Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial

Massimiliano Ruscica et al.

EUROPEAN JOURNAL OF NUTRITION (2018)

Article Dermatology

Pathophysiology of the metabolic syndrome

Emma McCracken et al.

CLINICS IN DERMATOLOGY (2018)

Review Peripheral Vascular Disease

The Global Epidemic of the Metabolic Syndrome

Mohammad G. Saklayen

CURRENT HYPERTENSION REPORTS (2018)

Review Nutrition & Dietetics

Soy, Soy Foods and Their Role in Vegetarian Diets

Gianluca Rizzo et al.

NUTRIENTS (2018)

Review Nutrition & Dietetics

Soybean Bioactive Peptides and Their Functional Properties

Cynthia Chatterjee et al.

NUTRIENTS (2018)

Article Nutrition & Dietetics

Effects of Genistein on Differentiation and Viability of Human Visceral Adipocytes

Elena Grossini et al.

NUTRIENTS (2018)

Review Endocrinology & Metabolism

Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Jahangir Iqbal et al.

CURRENT DIABETES REVIEWS (2018)

Article Food Science & Technology

Metabolic programming of a beige adipocyte phenotype by genistein

Sadat A. Aziz et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

Review Cell Biology

Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Gemma Chiva-Blanch et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Medicine, General & Internal

Obesity and inflammation: the linking mechanism and the complications

Mohammed S. Ellulu et al.

ARCHIVES OF MEDICAL SCIENCE (2017)

Article Cardiac & Cardiovascular Systems

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

Jose J. Fuster et al.

CIRCULATION RESEARCH (2016)

Article Environmental Sciences

Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs

Hua-ping Zhang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016)

Article Nutrition & Dietetics

Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts

M. Ding et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2016)

Article Endocrinology & Metabolism

Adiponectin, Insulin Sensitivity and Diabetic Retinopathy in Latinos With Type 2 Diabetes

Jane Z. Kuo et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Medicine, Research & Experimental

Abdominal obesity: a marker of ectopic fat accumulation

Ulf Smith

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Biochemistry & Molecular Biology

Oxidative Stress in Obesity: A Critical Component in Human Diseases

Lucia Marseglia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Nursing

Prevalence of metabolic syndrome and cardiovascular risk level in a vulnerable population

Chun-Ja Kim et al.

INTERNATIONAL JOURNAL OF NURSING PRACTICE (2015)

Review Endocrinology & Metabolism

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

Nathalie Esser et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2014)

Article Food Science & Technology

Intakes of total and individual flavonoids by US adults

Wei Bai et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2014)

Review Biochemistry & Molecular Biology

Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux

Yolanda F. Otero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Medicine, General & Internal

Thrombosis formation on atherosclerotic lesions and plaque rupture

L. Badimon et al.

JOURNAL OF INTERNAL MEDICINE (2014)

Review Biochemistry & Molecular Biology

Phytoestrogens and the metabolic syndrome

Alois Jungbauer et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Article Medicine, General & Internal

Biochemistry of adipose tissue: an endocrine organ

Marisa Coelho et al.

ARCHIVES OF MEDICAL SCIENCE (2013)

Article Obstetrics & Gynecology

Daidzein improves insulin resistance in ovariectomized rats

Y. K. Cao et al.

CLIMACTERIC (2013)

Article Medicine, General & Internal

Genistein and endothelial function in postmenopausal women with metabolic syndrome

Concetta Irace et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Pharmacology & Pharmacy

Isoflavones: estrogenic activity, biological effect and bioavailability

Daniela Cristina Vitale et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2013)

Article Endocrinology & Metabolism

Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

Francesco Squadrito et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Review Nutrition & Dietetics

Body Fat Distribution and Insulin Resistance

Pavankumar Patel et al.

NUTRIENTS (2013)

Article Nutrition & Dietetics

Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes

Zhuo Fu et al.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME (2012)

Article Pharmacology & Pharmacy

The Role of Nitric Oxide on Endothelial Function

Dimitris Tousoulis et al.

CURRENT VASCULAR PHARMACOLOGY (2012)

Review Endocrinology & Metabolism

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

Biagio Arcidiacono et al.

EXPERIMENTAL DIABETES RESEARCH (2012)

Review Endocrinology & Metabolism

Metabolic alterations following visceral fat removal and expansion Beyond anatomic location

Michelle T. Foster et al.

ADIPOCYTE (2012)

Review Biochemistry & Molecular Biology

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

Hajime Otani

ANTIOXIDANTS & REDOX SIGNALING (2011)

Review Immunology

Adipokines in inflammation and metabolic disease

Noriyuki Ouchi et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Review Pharmacology & Pharmacy

Insulin Resistance in Nonalcoholic Fatty Liver Disease

E. Bugianesi et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Article Nutrition & Dietetics

Equol: History, Chemistry, and Formation

Kenneth D. R. Setchell et al.

JOURNAL OF NUTRITION (2010)

Review Physiology

Nitric oxide and oxidative stress in vascular disease

Ulrich Foerstermann

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Metabolic Syndrome Increases Mortality in Heart Failure

Leonardo Tamariz et al.

CLINICAL CARDIOLOGY (2009)

Article Cell Biology

A comprehensive definition for metabolic syndrome

Paul L. Huang

DISEASE MODELS & MECHANISMS (2009)

Article Nutrition & Dietetics

Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form:: a randomized, double-blind, crossover study

Corinna E. Rufer et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)

Article Endocrinology & Metabolism

Metabolic syndrome: do clinical criteria identify similar individuals among overweight premenopausal women?

Sofiya Alhassan et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2008)

Review Medicine, General & Internal

The metabolic syndrome: Concepts and controversy

Lewis W. Johnson et al.

MAYO CLINIC PROCEEDINGS (2006)

Article Nutrition & Dietetics

Bioavailability of isoflavones after ingestion of soy beverages in healthy adults

Mitsuyoshi Kano et al.

JOURNAL OF NUTRITION (2006)

Article Endocrinology & Metabolism

Insulin resistance in PCOS

Evanthia Diamanti-Kandarakis

ENDOCRINE (2006)

Article Clinical Neurology

Insulin resistance, inflammation, and cognition in Alzheimer's Disease:: Lessons for multiple sclerosis

G. Stennis Watson et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)

Article Endocrinology & Metabolism

Dose-response effect of elevated plasma free fatty acid on insulin signaling

R Belfort et al.

DIABETES (2005)

Review Endocrinology & Metabolism

Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes

G Boden

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2003)

Article Medicine, Research & Experimental

Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Physiology

The pathophysiology of type 2 diabetes mellitus:: an overview

CG Östenson

ACTA PHYSIOLOGICA SCANDINAVICA (2001)

Article Medicine, Research & Experimental

Insulin resistance and cardiovascular disease

HN Ginsberg

JOURNAL OF CLINICAL INVESTIGATION (2000)