In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.

Automated summary

The study investigates the active ingredients in red wines and their interactions with serum proteins. Components like rutin, resveratrol, and tannic acid show good binding affinity and beneficial properties for potential clinical applications. Red wines contain flavonoids, non-flavonoids, and phenolic acids which can enhance biological activity by interacting with key regions of proteins.