Recent Advances in Visible-Light-Mediated Amide Synthesis

Visible-light photoredox catalysis has attracted tremendous interest within the synthetic community. As such, the activation mode potentially provides a more sustainable and efficient platform for the activation of organic molecules, enabling the invention of many controlled radical-involved reactions under mild conditions. In this context, amide synthesis via the strategy of photoredox catalysis has received growing interest due to the ubiquitous presence of this structural motif in numerous natural products, pharmaceuticals and functionalized materials. Employing this strategy, a wide variety of amides can be prepared effectively from halides, arenes and even alkanes under irradiation of visible light. These methods provide a robust alternative to well-established strategies for amide synthesis that involve condensation between a carboxylic acid and amine mediated by a stoichiometric activating agent. In this review, the representative progresses made on the synthesis of amides through visible light-mediated radical reactions are summarized.

Automated summary

Visible-light photoredox catalysis has gained significant attention in the synthetic community due to its potential for sustainable and efficient activation of organic molecules. Amide synthesis through photoredox catalysis has become increasingly popular as it allows for the preparation of a wide variety of amides from halides, arenes, and alkanes using visible light irradiation. These methods offer an alternative to traditional amide synthesis strategies involving stoichiometric activating agents.