Journal
MOLECULES
Volume 26, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/molecules26216665
Keywords
copper nanoparticles; MCF-7 breast cancer cell; cytotoxicity screening; DNA fragmentation; fluorescence microscopy
Funding
- King Saud University, Riyadh, Saudi Arabia [RSP-2021/27]
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Copper nanoparticles synthesized using copper(II)-tyrosinase from potato peel powder showed potential cytotoxicity against MCF-7 breast cancer cells, indicating their possible use as anticancer agents in future research.
The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyrosinase with N-aminoethylethanolamine to produce Cu(II)-NPs and these were characterized by means of FT-IR, UV-Spectroscopy, XRD, SEM, TEM and a particle size analyzer. These Tyr-Cu(II)-AEEA NPs were tested as anticancer agents against MCF-7 breast cancer cells. Fluorescence microscopy and DNA fragmentation were also performed, which revealed the inhibiting potentials of Cu(II)-AEEA NPs and consequent cell death; Tyr-Cu(II)-AEEA NPs show potential cytotoxicity activity and this nano material could be contemplated as an anticancer medicament in future investigations.
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