Journal
MOLECULES
Volume 27, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules27020558
Keywords
deep eutectic solvents; 2-mercaptoquinazolin-4(3H)-one; microwave-assisted synthesis; ultrasound-assisted synthesis; green chemistry
Funding
- Croatian Science Foundation under the project Green Technologies in Synthesis of Heterocyclic compounds [UIP-2017-05-6593]
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In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones. Using different temperatures and DES systems, the desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. The specific contribution of this research is the use of DESs in combination with green techniques for the synthesis of a wide range of derivatives.
In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and phenyl isothiocyanate was performed in 20 choline chloride-based DESs at 80 degrees C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly, higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The specific contribution of this research is the use of DESs in combination with the above-mentioned green techniques for the synthesis of a wide range of derivatives. The structures of the synthesized compounds were confirmed by H-1 and C-13 NMR spectroscopy.
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