4.6 Article

The Flow of Blood-Based Hybrid Nanofluids with Couple Stresses by the Convergent and Divergent Channel for the Applications of Drug Delivery

Journal

MOLECULES
Volume 26, Issue 21, Pages -

Publisher

MDPI
DOI: 10.3390/molecules26216330

Keywords

stretchable/shrinkable walls; hybrid nanofluid; drug delivery; couple stresses; Darcy-Forchheimer model; heat absorption/omission (HAM)

Funding

  1. Center of Excellence in Theoretical and Computational Science (TaCS-CoE), KMUTT
  2. Thailand Science Research and Innovation (TSRI) Basic Research Fund [64A306000005]

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This research scrutinizes the mathematical model for hybrid nanofluid flow in converging and diverging channels, focusing on drug delivery applications. The study reveals that combining TiO2 with other metals can more effectively destroy cancer cells, while increasing the couple stress parameter improves the stability of the base fluid and affects heat transfer rate based on nanoparticle volume fraction.
This research work aims to scrutinize the mathematical model for the hybrid nanofluid flow in a converging and diverging channel. Titanium dioxide and silver (TiO2 and Ag) are considered as solid nanoparticles while blood is considered a base solvent. The couple-stress fluid model is essentially use to describe the blood flow. Therefore, the couple-stress term was used in the recent study with the existence of a magnetic field and a Darcy-Forchheiner porous medium. The heat absorption/omission and radiation terms were also included in the energy equation for the sustainability of drug delivery. An endeavor was made to link the recent study with the applications of drug delivery. It has already been revealed by the available literature that the combination of TiO2 with any other metal can destroy cancer cells more effectively than TiO2 separately. Both the walls are stretchable/shrinkable, whereas flow is caused by a source or sink with alpha as a converging/diverging parameter. Governing equations were altered into the system of non-linear coupled equations by using the similarity variables. The homotopy analysis method (HAM) was applied to obtain the preferred solution. The influences of the modeled parameters have been calculated and displayed. The confrontation of wall shear stress and hybrid nanofluid flow increased as the couple stress parameter rose, which indicates an improvement in the stability of the base fluid (blood). The percentage (%) increase in the heat transfer rate with the variation of nanoparticle volume fraction was also calculated numerically and discussed theoretically.

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