Journal
MOLECULES
Volume 26, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/molecules26226898
Keywords
Sargassum horneri; (-)-Loliode; UVB irradiation; ROS; MMPs
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [2019R1A6A1A03033553]
- Ocean University of China [862101013159]
- National Research Foundation of Korea [2019R1A6A1A03033553] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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(-)-loliode, a compound isolated from the brown seaweed Sargassum horneri, has strong antioxidant and anti-inflammatory activities, showing significant photoprotective effects in skin cells in vitro and in zebrafish in vivo. This suggests that (-)-loliode may be an ideal ingredient in pharmaceutical and cosmeceutical industries for skin damage protection.
Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed Sargassum horneri, showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries.
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