Diels-Alder Cycloaddition Reactions in Sustainable Media

Diels-Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels-Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents (such as glycerol and gluconic acid), polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems. Issues such as method's scope, efficiency, selectivity and reaction mechanism, as well as sustainability, advantages and limitations of these reaction media, are addressed.

Automated summary

This review provides insights into the recent advances in sustainable Diels-Alder reactions since 2010, with a focus on various environmentally benign solvent systems. The scope, efficiency, selectivity, and reaction mechanism of these reaction media are discussed.