Journal
MOLECULES
Volume 27, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules27020334
Keywords
adipokine; metabolic syndrome; glucose intolerance; lipid metabolism
Funding
- Institute of Korea Health Industry Development Institute (KHIDI) - Korean government (Ministry of Health and Welfare, MOHW) [HI19C0806]
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This review summarizes the role of adipokines in the development of metabolic syndrome, with a focus on glucose homeostasis and lipid metabolism.
Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue, adipokines, play critical roles in the development of metabolic syndrome. Although the adipokines leptin and adiponectin improve insulin sensitivity, others contribute to the development of glucose intolerance, including visfatin, fetuin-A, resistin, and plasminogen activator inhibitor-1 (PAI-1). Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties. In this review, we briefly summarize the role of various adipokines in the development of metabolic syndrome, focusing on glucose homeostasis and lipid metabolism.
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