Journal
MOLECULES
Volume 26, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/molecules26216481
Keywords
triethylamine; Schiff base; protein modification
Funding
- National Science Foundation [CHE-1904749]
- National Institutes of Health [R01 GM135264-01]
Ask authors/readers for more resources
When trialkylamines are added to buffered solutions of peptides, unexpected Schiff base products can form due to the presence of aldehydes in the amines. Detection of aldehydes and addition of other amines can help minimize the undesirable effects of these adducts in proteomics experiments.
When trialkylamines are added to buffered solutions of peptides, unexpected adducts can be formed. These adducts correspond to Schiff base products. The source of the reaction is the unexpected presence of aldehydes in amines. The aldehydes can be detected in a few ways. Most importantly, they can lead to unanticipated results in proteomics experiments. Their undesirable effects can be minimized through the addition of other amines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available