Journal
MOLECULES
Volume 26, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/molecules26237379
Keywords
E; Z photoswitches; photoisomerization; two-photon absorption
Funding
- Junta de Andalucia [UMA18-FEDERJA-007]
- Spanish Ministry for Science, Innovation, and Universities [PID2019-104293GB-I00]
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Studying photoswitches activated by two-photon absorption (TPA) reveals that protonated Schiff-bases (retinal)-like photoswitches outperform other families, with theoretical predictions suggesting potential applications in optogenetics.
Nonlinear optical techniques as two-photon absorption (TPA) have raised relevant interest within the last years due to the capability to excite chromophores with photons of wavelength equal to only half of the corresponding one-photon absorption energy. At the same time, its probability being proportional to the square of the light source intensity, it allows a better spatial control of the light-induced phenomenon. Although a consistent number of experimental studies focus on increasing the TPA cross section, very few of them are devoted to the study of photochemical phenomena induced by TPA. Here, we show a design strategy to find suitable E/Z photoswitches that can be activated by TPA. A theoretical approach is followed to predict the TPA cross sections related to different excited states of various photoswitches' families, finally concluding that protonated Schiff-bases (retinal)-like photoswitches outperform compared to the others. The donor-acceptor substitution effect is therefore rationalized for the successful TPA activatable photoswitch, in order to maximize its properties, finally also forecasting a possible application in optogenetics. Some experimental measurements are also carried out to support our conclusions.
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