Journal
MOLECULES
Volume 27, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules27020400
Keywords
Belamcanda chinensis (L; ) DC; tectoridin; hair growth; alopecia
Funding
- Key-Area Research and Development Program of Guangdong Province [2020B1111110006]
- Special project of Foshan University of science and technology [FSUST19-SRI10]
- GBA Institute of Collaborate Innovation [GICI-022]
- Shenzhen Science and Technology Innovation Committee [ZDSYS201707281432317, JCYJ20170413173747440, JCYJ2018030 6174903174]
- Zhongshan Municipal Bureau of Science and Technology [ZSST20SC03]
- Guangzhou Science and Technology Committee Research Grant [GZSTI16SC02, GZSTI17SC02]
- Hong Kong RGC Theme-based Research Scheme [T13-605/18-W]
- Hong Kong Innovation Technology Fund [UIM/340, UIM/385, ITS/500/18FP, ITCPD/17-9, TUYF19SC02, PD18SC01, HMRF18SC06, HMRF20SC07, AFD20SC01]
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A study found that tectoridin, an isoflavone found in the ethanolic extract of Rhizoma Belamcandae, can promote hair growth by activating the Wnt signaling pathway. Experimental evidence demonstrates the hair-promoting effects of tectoridin on human follicular dermal papilla cells and mouse vibrissae.
To search hair growth-promoting herbal extract, a screening platform of having HEK293T fibroblast being transfected with pTOPFLASH DNA construct was developed over a thousand of herbal extracts and phytochemicals were screened. One of the hits was ethanolic extract of Rhizoma Belamcandae, the rhizome of Belamcanda chinensis (L.) DC. Tectoridin, an isoflavone from Rhizoma Belamcandae, was shown to be responsible for this activation of promoter construct, inducing the transcription of pTOPFLASH in the transfected fibroblasts in a dose-dependent manner. The blockage by DKK-1 suggested the action of tectoridin could be mediated by the Wnt receptor. The hair growth-promoting effects of tectoridin were illustrated in human follicular dermal papilla cells and mouse vibrissae organ cultures. In tectoridin-treated dermal papilla cultures, an activation of Wnt signaling was demonstrated by various indicative markers, including TCF/LEF1 transcriptional activity, nuclear translocation of beta-catenin, expressions level of mRNAs encoding axin-related protein, (AXIN2), beta-catenin, lymphoid enhancer-binding factor-1 (LEF-1), insulin-like growth factor 1 (IGF-1) and alkaline phosphatase (ALP). In addition, an increase of hair shaft elongation was observed in cultured mouse vibrissae upon the treatment of tectoridin. Tectoridin, as well as the herbal extract of Rhizoma Belamcandae, possesses hair promoting activity, which deserves further development.
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