Journal
MOLECULES
Volume 26, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/molecules26216545
Keywords
Hypericum scabrum; essential oil; chemical composition; antimicrobial activity; synergy
Funding
- Agence Nationale de la Recherche [CEBA, 165 ANR-10-LABX-25-01]
- CNRS Lebanon
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Lebanese Hypericum scabrum essential oil showed strong antifungal activity against filamentous fungi, potentially due to minor constituents. A synergistic effect was observed when combined with the antifungal drug amphotericin B.
The chemical composition of Lebanese Hypericum scabrum essential oil (EO) was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GG-MS). Its antimicrobial activity was evaluated by determining its minimal inhibitory concentrations (MICs) against a Gram-negative and a Gram-positive bacterium, one yeast, and five dermatophytes. H. scabrum EO was most active on filamentous fungi (MIC values of 32-64 mu g/mL). Synergy within the oil was investigated by testing each of the following major components on Trichophyton rubrum: alpha-pinene, limonene, myrcene, beta-pinene and nonane, as well as a reconstructed EO. The antifungal activity of the natural oil could not be reached, meaning that its activity might be due, in part, to minor constituent(s). The interactions between H. scabrum EO and commercially available antifungals were assessed by the checkerboard test. A synergistic effect was revealed in the combination of the EO with amphotericin B.
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