Journal
MOLECULES
Volume 26, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/molecules26237115
Keywords
diabetes mellitus; oxidative stress; inflammation; gallic acid
Funding
- Gala Family Trust [200007008, 260007830, 260007482]
- Health and Medical Research Fund [15162961,16172751]
Ask authors/readers for more resources
Diabetes mellitus is closely linked to oxidative stress, with natural antioxidants like gallic acid showing potential benefits for diabetes through their anti-inflammatory and antioxidative effects.
Diabetes mellitus (DM) is a severe chronic metabolic disease with increased mortality and morbidity. The pathological progression of DM is intimately connected with the formation and activation of oxidative stress (OS). Especially, the involvement of OS with hyperglycemia, insulin resistance, and inflammation has shown a vital role in the pathophysiological development of DM and related complications. Interestingly, accumulating studies have focused on the exploration of natural antioxidants for their improvement on DM. Of specific interest is gallic acid (GA), which is rich in many edible and herbal plants and has progressively demonstrated robust antioxidative and anti-inflammatory effects on metabolic disorders. To provide a better understanding of its potential therapeutic impacts and enhancement of human health care, the available research evidence supporting the effective antidiabetic properties of GA and relevant derivatives are needed to be summarized and discussed, with emphasis on its regulation on OS and inflammation against DM. This review aims to highlight the latest viewpoints and current research information on the role of OS in diabetes and to provide scientific support for GA as a potential antihypoglycemic agent for DM and its complications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available