☆ 4.6 Article

High diversity in Delta variant across countries revealed by genome-wide analysis of SARS-CoV-2 beyond the Spike protein

MOLECULAR SYSTEMS BIOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

Add to Collection

Article Microbiology

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Zhuoming Liu et al.

Summary: The study found that antibodies targeting the SARS-CoV-2 spike protein have escape mutations, different monoclonal antibodies have unique resistance profiles, some mutants are resistant to multiple antibodies while some variants can escape neutralization by convalescent sera. Comparing antibody-mediated mutations with circulating SARS-CoV-2 sequences revealed substitutions that may weaken neutralizing immune responses in some individuals, warranting further investigation.

CELL HOST & MICROBE (2021)

Add to Collection

Article Microbiology

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Gabriele Cerutti et al.

Summary: Structural analysis revealed that seven potent NTD-directed neutralizing antibodies target a common surface on NTD, forming a single supersite different from the recognition pattern of RBD-directed antibodies.

CELL HOST & MICROBE (2021)

Add to Collection

Article Multidisciplinary Sciences

Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles

Abdullah M. Syed et al.

Summary: Efforts to determine the improved fitness of new SARS-CoV-2 variants have been limited to analyzing spike protein mutations. This study shows that SC2-VLPs can deliver exogenous transcripts, allowing analysis of mutations in all structural proteins. Specific nucleocapsid mutations were found to independently increase messenger RNA delivery and expression, shedding light on mechanisms behind the increased spread of variants.

SCIENCE (2021)

Add to Collection

Article Virology

COVID-19, the first pandemic in the post-genomic era

Lucy van Dorp et al.

Summary: The unprecedented international efforts to sequence SARS-CoV-2 genomes have led to rapid characterization of the virus and successful vaccine development programs. Global genomic resources provide a good understanding of the pandemic and support monitoring of viral diversity, while continued genomic surveillance is crucial for informing the timing of vaccine updates. Room for improvement lies in less heterogeneous global surveillance and tools to rapidly identify concerning viral lineages.

CURRENT OPINION IN VIROLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

SARS-CoV-2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time-course study - potential challenge for vaccines and therapies

Stefanie Weber et al.

Summary: The study found that SARS-CoV-2 variants and mutants are rapidly evolving globally, including some new variants from the UK, South Africa, and Brazil. Despite lockdowns, active replication in genetically and socio-economically diverse populations worldwide has facilitated the emergence of new mutations.

EMBO MOLECULAR MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Analysis of SARS-CoV-2 nucleocapsid phosphoprotein N variations in the binding site to human 14-3-3 proteins

Samanta Del Veliz et al.

Summary: The study explored the interaction between the SARS-CoV-2 N protein and cell host proteins including 14-3-3γ, analyzing the impact of mutations on binding energy. Mutations with positive effects on the interaction were found to be most prevalent in the phylogenetic tree, with compensatory mutations identified to maintain interaction energy. The results suggest that the N-14-3-3γ binding is beneficial for the virus, highlighting the potential for targeting this viral-host protein-protein interaction in antiviral strategies.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Chang Liu et al.

Summary: Recent study examined the neutralizing ability of monoclonal antibodies, convalescent and vaccine sera against the Indian variants B.1.617.1 and B.1.617.2, showing that the neutralization of these variants is reduced compared to the ancestral strains, without widespread antibody escape as seen in other variants like B.1.351.

CELL (2021)

Add to Collection

Letter Medicine, General & Internal

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

Emma C. Wall et al.

LANCET (2021)

Add to Collection

News Item Multidisciplinary Sciences

COVID VACCINES SLASH VIRAL SPREAD - BUT DELTA IS AN UNKNOWN

Smriti Mallapaty

Summary: Although studies show vaccines reduce the spread of SARS-CoV-2 by more than 80%, the Delta variant is introducing fresh uncertainties.

NATURE (2021)

Add to Collection

News Item Multidisciplinary Sciences

HOW THE CORONAVIRUS INFECTS OUR CELLS

Megan Scudellari

NATURE (2021)

Add to Collection

Article Multidisciplinary Sciences

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

Jack Chun-Chieh Hsu et al.

Summary: SARS-CoV-2 shuts down host innate immune responses through the translation inhibition activity of NSP14, revealing insights into the pathogenesis of the virus.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Immunology

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications

Lishuang Shen et al.

Summary: Mutations in the SARS-CoV-2 Membrane (M) gene, particularly the recently identified M:I82T mutation, have seen a significant increase in frequency. This new sub-B.1 clade, B.1.I82T, suggests potential implications for viral replication and should be closely monitored for further evaluation.

EMERGING MICROBES & INFECTIONS (2021)

Add to Collection

Article Geosciences, Multidisciplinary

Crowdsourced air traffic data from the OpenSky Network 2019-2020

Martin Strohmeier et al.

Summary: The OpenSky Network is a non-profit association that crowdsources live air traffic control data broadcast by aircraft, which has been widely used for academic research. The demand for real-time and historical aircraft flight data has increased significantly during the COVID-19 outbreak.

EARTH SYSTEM SCIENCE DATA (2021)

Add to Collection

Article Biochemical Research Methods

SciPy 1.0: fundamental algorithms for scientific computing in Python

Pauli Virtanen et al.

NATURE METHODS (2020)

Add to Collection

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Markus Hoffmann et al.

MOLECULAR CELL (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Yuan Huang et al.

ACTA PHARMACOLOGICA SINICA (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Mutations in the phosphorylation sites of SARS-CoV-2 encoded nucleocapsid protein and structure model of sequestration by protein 14-3-3

H. Y. Lim Tung et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Add to Collection

Article Multidisciplinary Sciences

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi et al.

SCIENCE (2020)

Add to Collection

Article Virology

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Natacha S. Ogando et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Virology

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

Jin-Yan Li et al.

VIRUS RESEARCH (2020)

Add to Collection

Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

Add to Collection

Review Immunology

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens

Liangwei Duan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

News Item Multidisciplinary Sciences

COVID VACCINES: WHAT SCIENTISTS NOW WANT TO KNOW

Heidi Ledford et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Chemistry, Medicinal

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

Jonathan P. Davies et al.

ACS INFECTIOUS DISEASES (2020)

Add to Collection

Article Microbiology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

I-Yin Chen et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Editorial Material Infectious Diseases

GISAID: Global initiative on sharing all influenza data - from vision to reality

Yuelong Shu et al.

EUROSURVEILLANCE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

Haim Ashkenazy et al.

NUCLEIC ACIDS RESEARCH (2016)

Add to Collection

Article Biochemical Research Methods

UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches

Baris E. Suzek et al.

BIOINFORMATICS (2015)

Add to Collection

Article Biochemical Research Methods

Accelerated Profile HMM Searches

Sean R. Eddy

PLOS COMPUTATIONAL BIOLOGY (2011)

Add to Collection

Article Virology

The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

M Surjit et al.

JOURNAL OF VIROLOGY (2005)

Add to Collection

Article Biochemistry & Molecular Biology

MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform

K Katoh et al.

NUCLEIC ACIDS RESEARCH (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.