Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 66, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.202100874
Keywords
24-h urine; biomarker of exposure; blood; multi-mycotoxin method; vegan
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Funding
- BfR project [1322-670]
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Vegans have a higher exposure to the mycotoxin OTA compared to omnivores, but there is no significant difference in exposure to other mycotoxins. Further research is needed to evaluate mycotoxin exposure from plant-based diets.
Scope: Vegans might have a higher exposure to mycotoxins due to their heightened consumption of typical mycotoxin containing food sources. Yet, data on internal exposure among vegans in comparison to omnivores are currently lacking. Methods and Results: This cross-sectional study includes 36 vegans and 36 omnivores (50% females, 30-60 years). A set of 28 and 27 mycotoxins is analyzed in 24-h urine and serum samples, respectively, by validated multi-mycotoxin methods (HPLC-MS/MS). Ochratoxin A (OTA), 2'R-OTA, and enniatin B in serum as well as deoxynivalenol-glucuronide in 24-h urine are quantified in 57-100% of the samples. Serum OTA levels are twofold higher in vegans than in omnivores (median 0.24 ng mL(-1) vs 0.12 ng mL(-1); p < 0.0001). No further significant differences were observed. Serum OTA levels are associated with intake of vegan products (r = 0.50, p < 0.0001) and pasta & rice (r = 0.33, p = 0.006). Sensitivity analyses advise cautious interpretation. Furthermore, serum levels of 2'R-OTA are related to coffee consumption (r = 0.64, p < 0.0001). Conclusion: The results indicate a higher exposure of vegans to OTA, but not to other mycotoxins. However, larger studies with repeated measurements are required to better evaluate the exposure to mycotoxins from plant-based diets.
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