Journal
MOLECULAR NEUROBIOLOGY
Volume 59, Issue 4, Pages 2620-2628Publisher
SPRINGER
DOI: 10.1007/s12035-021-02721-2
Keywords
circRNA; Spinal cord injury; ceRNA; microRNA
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Spinal cord injury (SCI) is a disabling condition with limited therapeutic options. Recent studies have shown altered expression of circular RNAs (circRNAs) in the damaged tissue, which play a role in cellular processes relevant to SCI repair and regeneration. However, further investigation is needed to efficiently deliver these regulatory molecules in a cell-type specific manner before translating these findings into clinical benefits.
Spinal cord injury (SCI) is a disabling condition for which therapeutic options are limited. Increasing number of microarray and next-generation sequencing studies have demonstrated that SCI coincides with altered expression of circular RNAs (circRNAs) in the damaged tissue. Emerging functional evidence further pinpointed specific differentially expressed circRNAs (e.g., circ-HIPK3, cicRNA.7079, circRNA_01477, circRNA-2960, and circ_0001723) for their effects on cellular processes relevant to SCI repair and regeneration, including neuronal apoptosis, astrocyte activation, and neuroinflammation, via sponging SCI-related microRNAs. Although circRNAs and their target microRNAs appear to be good candidates for therapeutic exploitation in SCI, further investigation into the efficient delivery of these regulatory molecules in a cell-type specific manner is a pre-requisite for translating these basic discoveries into clinical benefits.
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