Journal
MOLECULAR NEUROBIOLOGY
Volume 59, Issue 3, Pages 1836-1849Publisher
SPRINGER
DOI: 10.1007/s12035-021-02662-w
Keywords
miRNAs; Diabetic complications; Diabetic neuropathy; Diabetic foot; Microvascular complications
Categories
Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
- DST-FIST grant [SR/FST/LS-I/2017/49]
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Accelerating cases of diabetes worldwide have led to increased incidences of diabetic complications. miRNAs play a significant role in the pathogenesis of diabetes mellitus and contribute to various complications. This review summarizes the involvement of miRNAs in diabetic neuropathy and the diabetic foot, and discusses the potential applications of miRNAs as biomarkers and therapeutic targets.
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus by affecting insulin release, beta-cell proliferation, and dysfunction. Besides, disrupted miRNAs contribute to various complications, diabetic retinopathy, nephropathy, and neuropathy as well as severe conditions like diabetic foot. MiRNAs regulate various processes involved in diabetic complications like angiogenesis, vascularization, inflammations, and various signaling pathways like PI3K, MAPK, SMAD, and NF-KB signaling pathways. Diabetic neuropathy is the most common diabetic complication, characterized mainly by pain and numbness, especially in the legs and feet. MiRNAs implicated in diabetic neuropathy include mir-9, mir-106a, mir-146a, mir-182, miR-23a and b, miR-34a, and miR-503. The diabetic foot is the most common diabetic neuropathy, often leading to amputations. Mir-203, miR-23c, miR-145, miR-29b and c, miR-126, miR-23a and b, miR-503, and miR-34a are associated with diabetic foot. This review has been compiled to summarize miRNA involved in initiation, progression, and miRNAs affecting various signaling pathways involved in diabetic neuropathy including the diabetic foot. Besides, potential applications of miRNAs as biomarkers and therapeutic targets in this microvascular complication will also be discussed.
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