☆ 4.6 Article

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?

MOLECULAR NEUROBIOLOGY (2022)

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Article Cell & Tissue Engineering

SARS-CoV-2 targets glial cells in human cortical organoids

Courtney L. McMahon et al.

Summary: Researchers used human stem cell-derived brain organoids to study how SARS-CoV-2 infects brain tissue and found that glial cells and cells of the choroid plexus were preferentially targeted, while neurons were not infected. The expression of angiotensin-converting enzyme 2 was detected in infected cells, but viral replication and cell death did not occur, indicating that this model serves as a feasible platform to study the cellular effects of SARS-CoV-2 infection in brain tissue.

STEM CELL REPORTS (2021)

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Review Immunology

Neuropathophysiology of coronavirus dsease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2 infection

Menizibeya O. Welcome et al.

Summary: COVID-19, caused by SARS-CoV-2, mainly affects the respiratory and gastrointestinal tracts but may also involve the central nervous system. Possible neuropathogenic mechanisms include downregulation of ACE2, increased activity of TMPRSS2 and cathepsin L, triggering neuroinflammatory response, and dysregulation of neurotransmitter signalling.

INFLAMMOPHARMACOLOGY (2021)

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Article Clinical Neurology

Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 long haulers

Edith L. Graham et al.

Summary: This study investigated the neurologic manifestations in non-hospitalized Covid-19 long haulers, revealing prominent symptoms such as brain fog and fatigue which negatively affect their cognition and quality of life.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

IL-6 Inhibition Reduces Neuronal Injury in a Murine Model of Ventilator-induced Lung Injury

Nicklaus A. Sparrow et al.

Summary: Mechanical ventilation is a risk factor for cognitive impairment, with upregulation of IL-6 potentially playing a role. Inhibiting systemic IL-6 could mitigate neuropathological effects associated with cognitive impairment, providing a potential novel neuroprotective strategy worth further investigation.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

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Article Biology

Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant

Susmit Mhatre et al.

Summary: This study found through computer simulation that catechins, especially epigallocatechin gallate, form favorable interactions with the spike protein of SARS-CoV-2, potentially impairing its function. This discovery encourages further exploration of the antiviral activity of catechins, particularly epigallocatechin gallate, against SARS-CoV-2 and its variants.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Targeting neuropilins as a viable SARS-CoV-2 treatment

Sarvenaz Sarabipour et al.

Summary: The SARS-CoV-2 pandemic has had a significant impact on global health, with research on viral mechanisms, vaccines, and therapies ongoing. Neuropilins have been identified as host cell receptors enabling viral fusion, but their central roles in various pathways may make them less suitable targets for treating SARS-CoV-2 compared to agents that target the viral spike protein.

FEBS JOURNAL (2021)

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Article Chemistry, Medicinal

Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening

Yuan Xiong et al.

Summary: This study aimed to discover naturally occurring SARS-CoV-2 3CL(pro) inhibitors from herbal constituents, with Ginkgo biloba leaves extract (GBLE) identified as the most potent inhibitor. The major constituents in GBLE exhibited strong SARS-CoV-2 3CL(pro) inhibition activities, offering promising compounds for developing novel anti-COVID-19 medications.

FITOTERAPIA (2021)

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Letter Infectious Diseases

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

Nouara Yahi et al.

JOURNAL OF INFECTION (2021)

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Article Clinical Neurology

A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications

Jennifer A. Frontera et al.

Summary: Long-term outcomes of COVID-19 hospitalized patients, particularly those with neurological complications, showed impairments in daily living activities, cognition, anxiety, depression, and sleep. Patients with neurological complications had significantly worse functional outcomes compared to those without.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Article Virology

SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

Keith Meyer et al.

Summary: Increased mortality in COVID-19 cases is often associated with microvascular complications. The spike protein of SARS-CoV-2 can induce cellular senescence and inflammatory responses in human epithelial cells, leading to enhanced leukocyte adhesion. Various inhibitors have shown potential in reversing the senescence effects and reducing inflammatory responses.

JOURNAL OF VIROLOGY (2021)

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Article Immunology

Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease

HariOm Singh et al.

Summary: Persistent SARS-CoV-2 infection may be associated with psychiatric and cognitive disorders, as well as neurological complications in adolescents and children. Immune-associated genes may play a role in the pathogenesis of COVID-19-associated neurological diseases, contributing to the identification of associated genetic risk factors.

MICROBIAL PATHOGENESIS (2021)

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Review Biochemistry & Molecular Biology

Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19

Ying-Qi Wang et al.

Summary: EGCG, the most abundant component of catechins in tea, plays an antiviral role by inhibiting virus invasiveness and gene replication. Its effects on various viruses, including DNA virus, RNA virus, coronavirus, enterovirus, and arbovirus, were reviewed in this paper. Additionally, the antiviral effects of its epi-isomer counterpart GCG were also discussed.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Dysregulation of brain and choroid plexus cell types in severe COVID-19

Andrew C. Yang et al.

Summary: This study found that patients with COVID-19 exhibited widespread cellular perturbations in the brain, including the relay of peripheral inflammation into the brain by choroid plexus barrier cells and infiltration of peripheral T cells. Additionally, COVID-19 affected synaptic signaling of upper-layer excitatory neurons linked to cognitive function.

NATURE (2021)

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Editorial Material Immunology

SARS-CoV-2 takes its Toll

Alan Sariol et al.

NATURE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Evdoxia Kyriazopoulou et al.

Summary: The SAVE-MORE phase 3 study demonstrated the efficacy of anakinra, an IL-1 alpha/beta inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, showing significant reduction in clinical deterioration and decreased 28-day mortality.

NATURE MEDICINE (2021)

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Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Editorial Material Medicine, General & Internal

Confronting Our Next National Health Disaster - Long-Haul Covid

Steven Phillips et al.

Summary: Long Covid could potentially become the next national health disaster, and it is important to address and find solutions for it.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Post-acute sequelae of COVID-19 in a non-hospitalized cohort: Results from the Arizona CoVHORT

Melanie L. Bell et al.

Summary: Clinical presentation, outcomes, and duration of COVID-19 vary greatly among individuals. Most PASC research has focused on hospitalized patients. A population-based study in Arizona found that 68.7% of non-hospitalized individuals experienced PASC symptoms 30 days post-infection, with fatigue, shortness-of-breath, brain fog, and stress/anxiety being the most common symptoms.

PLOS ONE (2021)

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Review Surgery

The impact of the COVID-19 pandemic on cerebrovascular disease

David I. Bass et al.

Summary: The COVID-19 pandemic initially raised concerns about the potential impact on ischemic stroke, but cohort studies globally have observed decreased rates of stroke admissions since the start of the pandemic. Patients infected with SARS-CoV-2 who present with stroke tend to have more severe outcomes and higher in-hospital mortality rates, but there is insufficient evidence to establish a direct causal relationship between the virus and the cerebral vasculature.

SEMINARS IN VASCULAR SURGERY (2021)

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Article Multidisciplinary Sciences

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO

Gabriel Jimenez-Avalos et al.

Summary: A virtual screening study identified potential compounds to inhibit the SARS-CoV-2 main protease through different pathways, with some compounds triggering novel structural mechanisms upon binding to allosteric sites. To ensure accurate analysis and interpretation, future screening campaigns against the main protease should consider key criteria and methods.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Heparan Sulfate Proteoglycans as Attachment Factor for SARSCoV-2

Lin Liu et al.

Summary: The study revealed the binding capability of SARS-CoV-2 spike protein with heparan sulfate (HS) and highlighted the potential therapeutic use of HS oligosaccharides. Heparin showed a higher affinity for SARS-CoV-2 spike protein compared to the receptor binding domain (RBD) alone, inhibiting RBD binding to cells. The findings support a model where HS acts as the initial attachment point for the virus to travel through the glycocalyx and engage with ACE2 for cell entry.

ACS CENTRAL SCIENCE (2021)

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Review Medicine, General & Internal

The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review

Monika Gudowska-Sawczuk et al.

Summary: NRP-1 plays a crucial role in SARS-CoV-2 infection by facilitating viral entry and potentially leading to neurological manifestations. Inhibiting NRP-1 has shown promise as a therapeutic strategy for treating SARS-CoV-2 infection. Additionally, NRP-1 may be associated with pathological changes in the retina during COVID-19.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Duration of post-COVID-19 symptoms is associated with sustained SARS-CoV-2-specific immune responses

Jacob K. Files et al.

Summary: Patients with prolonged post-COVID-19 symptom duration exhibit maintained SARS-CoV-2-specific immune responses, including antigen-specific T cell responses and increased IgG avidity to the virus, suggesting the persistence of viral antigens as a possible cause for the ongoing symptoms.

JCI INSIGHT (2021)

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Review Neurosciences

SARS-CoV-2: is there neuroinvasion?

Conor McQuaid et al.

Summary: The study reviewed the impact of SARS-CoV-2 on the brain, including its invasion routes and potential neurological manifestations. While there is limited evidence of direct brain infiltration by SARS-CoV-2, the presence of the virus in severely infected patients suggests the olfactory mucosa could be a possible entrance. Further studies are needed to confirm neuroinvasion pathways and understand the neurological complications of COVID-19 beyond respiratory distress.

FLUIDS AND BARRIERS OF THE CNS (2021)

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Article Biochemistry & Molecular Biology

Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer

Jingwen Yue et al.

Summary: This study reveals that the binding of heparan sulfate (HS) to SARS-CoV-2 spike protein (SV2-S) is essential for the virus to infect host cells, and can be inhibited by heparin lyase, HS antagonist surfen, heparin, and heparin derivatives. The higher infectivity of the SARS-CoV-2 G614 variant is attributed to its higher affinity to heparin/HS and increased HS expression on host cells, which can be effectively blocked by heparin lyase and heparin.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Health Care Sciences & Services

Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum Disorder

Theoharis C. Theoharides

Summary: The prevalence of autism spectrum disorder (ASD) is increasing, and while the exact pathogenesis and effective treatment remain unknown, research suggests that brain inflammation may play a significant role in neurodegenerative changes affecting emotions and fear regulation. Inflammation of the brain can be triggered by various factors, leading to disruptions in neuronal connectivity and emotional expression, as seen in ASD. Personalized treatment approaches targeting factors like mast cells and microglia activation may offer potential benefits for individuals with ASD.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration

Ling Zhang et al.

Summary: The study found evidence supporting that SARS-CoV-2 can cross the blood-brain barrier in transcellular pathways based on experiments in mice and hamsters. The transmission pathway involves disrupted basement membrane without obvious alteration of tight junctions.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, General & Internal

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact

Hannah E. Davis et al.

Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.

ECLINICALMEDICINE (2021)

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Article Immunology

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

Manish Sadarangani et al.

Summary: Most COVID-19 vaccines aim to induce immune responses, particularly neutralizing antibodies (NAbs), against the spike protein of the virus. mRNA vaccines have shown efficacy after just one dose, while adenovirus vaccines elicit polyfunctional antibodies and strong T cell responses. These findings suggest that protection may not solely rely on NAbs but also involve other immune effector mechanisms.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

Li Jiao et al.

Summary: This study investigated the neurotropism of SARS-CoV-2 in a non-human primate model and found that the virus primarily invades the central nervous system via the olfactory bulb, then quickly spreads to different functional regions, possibly inducing inflammation. This experimental evidence provides important insights into the CNS-related pathogenesis of SARS-CoV-2.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemical Research Methods

Prediction of Anti-COVID 19 Therapeutic Power of Medicinal Moroccan Plants Using Molecular Docking

Badreddine Nouadi et al.

Summary: The current focus of medical research is on discovering and developing new bioactive compounds with cost-effective and specific anti-COVID-19 therapeutic power, with the molecular docking technique being essential for understanding drug-target interactions in their natural environment.

BIOINFORMATICS AND BIOLOGY INSIGHTS (2021)

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Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Psychiatry

Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

Maxime Taquet et al.

Summary: This study found that survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and a psychiatric diagnosis might be an independent risk factor for COVID-19. These findings have implications for clinical services, and prospective cohort studies are warranted to further validate the results.

LANCET PSYCHIATRY (2021)

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Article Medicine, General & Internal

Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study

Andrea Dennis et al.

Summary: A study conducted in two UK community centers found that 70% of individuals with persistent symptoms following recovery from SARS-CoV-2 infection had impairment in one or more organs 4 months after initial COVID-19 symptoms. Common symptoms included fatigue, muscle aches, breathlessness, and headaches.

BMJ OPEN (2021)

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Review Clinical Neurology

Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease

Duraisamy Kempuraj et al.

NEUROSCIENTIST (2020)

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Review Chemistry, Medicinal

The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation

Zehra Calis et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Inhibition of SARS-CoV 3CL protease by flavonoids

Seri Jo et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

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Review Cell Biology

Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging

Gabriele Serreli et al.

CELLS (2020)

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Editorial Material Biochemistry & Molecular Biology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Editorial Material Biochemistry & Molecular Biology

COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

Theoharis C. Theoharides

BIOFACTORS (2020)

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Editorial Material Neurosciences

The COVID-19 Pandemic: Setting the Mental Health Research Agenda

Joshua A. Gordon et al.

BIOLOGICAL PSYCHIATRY (2020)

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Review Immunology

COVID-19 pandemic and mental health consequences: Systematic review of the current evidence

Nina Vindegaard et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Microbiology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Evangelos J. Giamarellos-Bourboulis et al.

CELL HOST & MICROBE (2020)

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Article Immunology

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Wanbo Tai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Pharmacology & Pharmacy

COVID-19 and Depression

Richard I. Shader

CLINICAL THERAPEUTICS (2020)

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Article Dermatology

Novel coronavirus disease 2019 (COVID-19) and neurodegenerative disorders

Anurag Kumar Singh et al.

DERMATOLOGIC THERAPY (2020)

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Article Allergy

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Tobias Herold et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Editorial Material Multidisciplinary Sciences

Cytokine release syndrome in severe COVID-19

John B. Moore et al.

SCIENCE (2020)

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Review Virology

Immunoregulation with mTOR inhibitors to prevent COVID-19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines

Yunfeng Zheng et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Editorial Material Psychiatry

Addressing the COVID-19 Pandemic in Populations With Serious Mental Illness

Benjamin G. Druss

JAMA PSYCHIATRY (2020)

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Article Multidisciplinary Sciences

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Axel Montagne et al.

NATURE (2020)

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Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Considerations around the SARS-CoV-2 Spike Protein with Particular Attention to COVID-19 Brain Infection and Neurological Symptoms

Kambiz Hassanzadeh et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Clinical Neurology

COVID-19: A Global Threat to the Nervous System

Igor J. Koralnik et al.

ANNALS OF NEUROLOGY (2020)

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Review Biology

Neuropathogenesis of SARS-CoV-2 infection

Shumayila Khan et al.

ELIFE (2020)

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Review Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Yujun Tang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The COVID-19 Cytokine Storm; What We Know So Far

Dina Ragab et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Neurosciences

Neurobiology of COVID-19

Majid Fotuhi et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Multidisciplinary Sciences

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

David H. Brann et al.

SCIENCE ADVANCES (2020)

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Article Medicine, Research & Experimental

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Alessio Mazzoni et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Virology

Prognostic value of interleukin-6, C -reactive protein, patients with COVID-19 and procalcitonin in

Fang Liu et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Review Immunology

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

Souhel Najjar et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Review Clinical Neurology

Neurological associations of COVID-19

Mark A. Ellul et al.

LANCET NEUROLOGY (2020)

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Article Biochemistry & Molecular Biology

Roles of flavonoids against coronavirus infection

Maria Russo et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Article Clinical Neurology

COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation

Duraisamy Kempuraj et al.

NEUROSCIENTIST (2020)

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Editorial Material Medicine, General & Internal

Mental Health and the Covid-19 Pandemic

Betty Pfefferbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Pharmacology & Pharmacy

Coronavirus 2019, Microthromboses, and Platelet Activating Factor

Theoharis C. Theoharides et al.

CLINICAL THERAPEUTICS (2020)

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Review Physiology

COVID-19 and the Immune System

Jan Paces et al.

PHYSIOLOGICAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 targets neurons of 3D human brain organoids

Anand Ramani et al.

EMBO JOURNAL (2020)

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Article Multidisciplinary Sciences

Distinct conformational states of SARS-CoV-2 spike protein

Yongfei Cai et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Transplacental transmission of SARS-CoV-2 infection

Alexandre J. Vivanti et al.

NATURE COMMUNICATIONS (2020)

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Editorial Material Medicine, General & Internal

Psychiatry and COVID-19

Dost Ongur et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Allergy

Highways to hell: Mechanism-based management of cytokine storm syndromes

Scott W. Canna et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

Ana Copaescu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Clinical Neurology

Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions

T. T. Favas et al.

NEUROLOGICAL SCIENCES (2020)

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Article Immunology

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

Jarbas da Silva Motta Junior et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Clinical Neurology

Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients

Eric M. Liotta et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

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Editorial Material Biochemistry & Molecular Biology

Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome

Abdul Mannan Baig

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Neurosciences

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier

Tetyana P. Buzhdygan et al.

NEUROBIOLOGY OF DISEASE (2020)

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Letter Medicine, General & Internal

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Bina Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults

Gabriele Gratton et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

Yixin Xie et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Review Medicine, General & Internal

The Role of Molecular Chaperones in Virus Infection and Implications for Understanding and Treating COVID-19

Letizia Paladino et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

COVID-19, microthromboses, inflammation, and platelet activating factor

Constantinos Demopoulos et al.

BIOFACTORS (2020)

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Review Clinical Neurology

COVID-19 and cerebrovascular diseases: a comprehensive overview

Georgios Tsivgoulis et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2020)

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Review Neurosciences

Neuropathobiology of COVID-19: The Role for Glia

Marie-Eve Tremblay et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection

Liam Townsend et al.

PLOS ONE (2020)

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Review Psychiatry

Psychiatric face of COVID-19

Luca Steardo et al.

TRANSLATIONAL PSYCHIATRY (2020)

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Review Critical Care Medicine

Neurological manifestations of COVID-19: a systematic review

Gaurav Nepal et al.

CRITICAL CARE (2020)

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Article Medicine, General & Internal

COVID-19-associated brief psychotic disorder

Colin M. Smith et al.

BMJ CASE REPORTS (2020)

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Article Immunology

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Huan Han et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Pharmacology & Pharmacy

Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary

Spencer Richman et al.

CLINICAL THERAPEUTICS (2019)

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Review Immunology

Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

Theoharis C. Theoharides et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)

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Article Chemistry, Medicinal

Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression

Haiyan Yan et al.

JOURNAL OF NATURAL MEDICINES (2019)

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Review Biochemistry & Molecular Biology

Mast Cell Responses to Viruses and Pathogen Products

Jean S. Marshall et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Neurosciences

Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome

Theoharis C. Theoharides et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Virology

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

Yushun Wan et al.

JOURNAL OF VIROLOGY (2019)

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Article Biochemistry & Molecular Biology

Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation

Zhao-Hui Yao et al.

NEUROCHEMICAL RESEARCH (2018)

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Review Biochemistry & Molecular Biology

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

Larisa Ryskalin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review

Zeinab Ashaari et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin

Alexandra Taracanova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Endocrinology & Metabolism

Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System

Ana Clara Liberman et al.

NEUROIMMUNOMODULATION (2018)

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Article Pharmacology & Pharmacy

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells

Arti B. Patel et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

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Review Behavioral Sciences

Mast cells in neuroinflammation and brain disorders

Erik Hendriksen et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

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Review Clinical Neurology

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

Stephen D. Skaper et al.

NEUROSCIENTIST (2017)

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Article Biochemistry & Molecular Biology

A structural mechanism of flavonoids in inhibiting serine proteases

Guangpu Xue et al.

FOOD & FUNCTION (2017)

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Article Oncology

Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression

A. Mayado et al.

LEUKEMIA (2016)

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Article Cell Biology

Induction of Microglial Activation by Mediators Released from Mast Cells

Xiang Zhang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

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Article Allergy

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

Avanti Desai et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Article Immunology

Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis

Xiang Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Neurosciences

Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats

Tzu Yu Lin et al.

NEUROTOXICOLOGY (2016)

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Article Multidisciplinary Sciences

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

Arti B. Patel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Geriatrics & Gerontology

Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice

Michael D. Burton et al.

REJUVENATION RESEARCH (2016)

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Article Virology

Antiviral activity of luteolin against Japanese encephalitis virus

Wenchun Fan et al.

VIRUS RESEARCH (2016)

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Article Immunology

C-kit mutations determine dasatinib mechanism of action in HMC-1 neoplastic mast cells: dasatinib differently regulates PKCδ translocation in HMC-1560 and HMC-1560,816 cell lines

Araceli Tobio et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2015)

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Article Allergy

The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

Zuyi Weng et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Review Medicine, General & Internal

Mast Cells, Mastocytosis, and Related Disorders

Theoharis C. Theoharides et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Psychiatry

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

I. Tsilioni et al.

TRANSLATIONAL PSYCHIATRY (2015)

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Review Neurosciences

Brain fog, inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Theoharis C. Theoharides et al.

FRONTIERS IN NEUROSCIENCE (2015)

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Editorial Material Pharmacology & Pharmacy

Brain Inflammation, Neuropsychiatric Disorders, and Immunoendocrine Effects of Luteolin

Theoharis C. Theoharides et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2014)

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Article Virology

Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening

Lin Xu et al.

VIRUSES-BASEL (2014)

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Review Geriatrics & Gerontology

Efficacy and tolerability of Ginkgo biloba extract EGb 761 (R) in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials

Serge Gauthier et al.

CLINICAL INTERVENTIONS IN AGING (2014)

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Article Pharmacology & Pharmacy

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

Anilia Taliou et al.

CLINICAL THERAPEUTICS (2013)

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Article Cardiac & Cardiovascular Systems

Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways

Jia-Shiong Chen et al.

CARDIOVASCULAR DIABETOLOGY (2012)

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Article Multidisciplinary Sciences

Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression

Daniela Silva Moura et al.

PLOS ONE (2012)

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Article Allergy

Mast cell activation syndrome: Proposed diagnostic criteria

Cem Akin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Cell Biology

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

Kavon Rezai-Zadeh et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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Article Immunology

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression

Kavon Rezai-Zadeh et al.

JOURNAL OF NEUROINFLAMMATION (2008)

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Article Multidisciplinary Sciences

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

Saebyeol Jang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Psychiatry

Ginkgo biloba special extract EGb 761® in generalized anxiety disorder and adjustment disorder with anxious mood:: A randomized, double-blind, placebo-controlled trial

H. Woelk et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2007)

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Review Biochemistry & Molecular Biology

Corticotropin-releasing hormone and the blood-brain-barrier

Theoharis C. Theoharides et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2007)

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Article Immunology

Detection of severe acute respiratory syndrome coronavirus in the brain: Potential role of the chemokine mig in pathogenesis

J Xu et al.

CLINICAL INFECTIOUS DISEASES (2005)

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Article Immunology

IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis

K Brockow et al.

CLINICAL IMMUNOLOGY (2005)

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Article Cardiac & Cardiovascular Systems

Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in apolipoprotein E knockout mice

M Huang et al.

CARDIOVASCULAR RESEARCH (2003)

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Article Immunology

IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells

K Kandere-Grzybowska et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Allergy

Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients

TC Theoharides et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2002)

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