Journal
MOLECULAR MEDICINE
Volume 28, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s10020-022-00439-y
Keywords
CYLD; IKK; NRF2; NF-kappa B; RIPK1
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Oxidative stress plays a significant role in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been identified. However, contradictory explanations regarding the mechanisms involved need clarification.
Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. However, contradictory explanations about the functioning of the mechanisms that will be effective in the pathogenesis require clarification.
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