Journal
MOLECULAR INFORMATICS
Volume 41, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/minf.202100285
Keywords
analog series; cheminformatics; Constellation Plots; drug discovery; Chemical Library Networks
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Funding
- DGAPA, UNAM, Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (UNAM-DGAPAPAPIIT) [IN201321]
- University of Florida
- Consejo Nacional de Ciencia y Tecnologia (CONACyT), Mexico
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The importance of epigenetic drug and probe discovery is increasing, aiding in the development of therapeutic treatments and understanding underlying epigenetic mechanisms in biological processes. Through comprehensive analysis of eleven libraries focused on epigenetic targets, guidance is provided for experimental groups working with high-throughput and medium-throughput screening of epigenetic-focused libraries, and as a reference for designing novel focused epigenetic libraries.
The importance of epigenetic drug and probe discovery is on the rise. This is not only paramount to identify and develop therapeutic treatments associated with epigenetic processes but also to understand the underlying epigenetic mechanisms involved in biological processes. To this end, chemical vendors have been developing synthetic compound libraries focused on epigenetic targets to increase the probabilities of identifying promising starting points for drug or probe candidates. However, the chemical contents of these data sets, the distribution of their physicochemical properties, and diversity remain unknown. To fill this gap and make this information available to the scientific community, we report a comprehensive analysis of eleven libraries focused on epigenetic targets containing more than 50,000 compounds. We used well-validated chemoinformatics approaches to characterize these sets, including novel methods such as automated detection of analog series and visual representations of the chemical space based on Constellation Plots and Chemical Library Networks. This work will guide the efforts of experimental groups working on high-throughput and medium-throughput screening of epigenetic-focused libraries. The outcome of this work can also be used as a reference to design and describe novel focused epigenetic libraries.
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