Journal
MOLECULAR IMMUNOLOGY
Volume 139, Issue -, Pages 193-201Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2021.07.024
Keywords
Fc receptors; Dendritic cells; Immune complexes; Fc gamma R; FcRn
Categories
Funding
- National Health and Medical Research Council [1058193, 1154502, 1016629, 1163090, 1113293, 1161101, 1129672]
- Australian Research Council [110101383, 160103134, 190101242, 180100844, 160101373, 180100521]
- National Institutes of Health [1R01AI148407-01A1]
- Human Fron-tier Science Program [0064/2011]
- National Health and Medical Research Council of Australia [1129672, 1154502, 1161101, 1163090, 1058193] Funding Source: NHMRC
Ask authors/readers for more resources
Dendritic cells (DCs) express receptors to sense pathogens and communicate with other immune cells. Fc receptors (FcRs) play a crucial role in DC immunity, affecting antigen uptake, presentation, DC maturation, and polarization of T cell responses.
Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of Fc gamma R and neonatal Fc receptor (FcRn) in DC immunity will be discussed. Their expression in DC subsets and impact on antigen uptake and presentation, DC maturation and polarisation of T cell responses will be described. Lastly, we will discuss the importance of FcR-mediated DC function in the context of immunity during viral infection, inflammatory disease, cancer and immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
