Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Shi et al. (2021) demonstrate that tumor-suppressive and developmental functions of UTX require an intrin-sically disordered region (IDR) capable of condensate formation. These results provide further evidence for the functional role of IDR-mediated spatial organization in regulating gene expression in development and disease.

Automated summary

The study by Shi et al. demonstrates that the tumor-suppressive and developmental functions of UTX rely on an intrinsically disordered region (IDR) capable of forming condensates. These findings further support the functional role of IDR-mediated spatial organization in regulating gene expression in development and disease.