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Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function

Journal

MOLECULAR CELL
Volume 82, Issue 4, Pages 716-727

Publisher

CELL PRESS
DOI: 10.1016/j.molcel.2021.12.004

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Funding

  1. NIH [R35GM131678-01, R01HD094400]

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Protein acetylation is a highly conserved post-translational modification and has been recognized for its importance in chromatin organization and DNA processes for nearly 60 years. Recent advances have revealed new roles of acetylation regulators and their complex functional networks.
Protein acetylation is conserved across phylogeny and has been recognized as one of the most prominent post-translational modifications since its discovery nearly 60 years ago. Histone acetylation is an active mark characteristic of open chromatin, but acetylation on specific lysine residues and histone variants occurs in different biological contexts and can confer various outcomes. The significance of acetylation events is indicated by the associations of lysine acetyltransferases, deacetylases, and acetyl-lysine readers with developmental disorders and pathologies. Recent advances have uncovered new roles of acetylation regulators in chromatin-centric events, which emphasize the complexity of these functional networks. In this review, we discuss mechanisms and dynamics of acetylation in chromatin organization and DNA-templated processes, including gene transcription and DNA repair and replication.

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