4.6 Article

Autophagy awakens-the myriad roles of autophagy in head and neck cancer development and therapeutic response

Journal

MOLECULAR CARCINOGENESIS
Volume 61, Issue 2, Pages 243-253

Publisher

WILEY
DOI: 10.1002/mc.23372

Keywords

autophagy; cancer; chemotherapy; radiation

Funding

  1. University of Wisconsin Carbone Cancer Center Support Grant [P30 CA014520]
  2. UW Head and Neck SPORE Grant [P50 DE026787]
  3. American Cancer Society Research Scholar Grant [RSG-16-091-01-TBG]
  4. Mission Boost Grant [BG-18-205-01-COUN]

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Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Dysregulation of autophagy can lead to various human diseases and cancers due to its complexity in regulating vital cellular functions. The role of autophagy in cancer development, progression, and treatment is complex, especially given its modulation by most cancer therapies.
Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Recycling of these cellular components occurs in a series of sequential steps with multiple regulatory points. Mechanistic dysfunction can lead to a variety of human diseases and cancers due to the complexity of autophagy and its ability to regulate vital cellular functions. The role that autophagy plays in both the development and treatment of cancer is highly complex, especially given the fact that most cancer therapies modulate autophagy. This review aims to discuss the balance of autophagy in the development, progression, and treatment of head and neck cancer, as well as highlighting the need for a deeper understanding of what is still unknown about autophagy.

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