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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
David R. Anderson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Smooth muscle α-actin expression and myofibroblast differentiation by TGFβ are dependent upon MK2
Anne Marie Sousa et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
Andre White et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Crystal structure of the P38α-MAPKAP kinase 2 heterodimer
Ernst ter Haar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-α mRNA
Lei Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
H. Christian Reinhardt et al.
CANCER CELL (2007)
The small heat shock proteins and their clients
H. Nakamoto et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
N. Ronkina et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin - A novel mechanism involved in vascular inflammation
Feng-Yen Lin et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity - Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
Ainsley A. Culbert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
CDC25B phosphorylation by p38 and MK-2
Matthieu Lemaire et al.
CELL CYCLE (2006)
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis
Martin Hegen et al.
JOURNAL OF IMMUNOLOGY (2006)
High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms
M. Pomérance et al.
JOURNAL OF PATHOLOGY (2006)
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
E Hitti et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration
M Kobayashi et al.
EMBO JOURNAL (2006)
Protein expression of TNF-α in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2
C Johansen et al.
JOURNAL OF IMMUNOLOGY (2006)
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding
XZ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The basic science of wound healing
George Broughton et al.
PLASTIC AND RECONSTRUCTIVE SURGERY (2006)
Leukocyte-specific protein 1 (LSP1) - A regulator of leukocyte emigration in inflammation
Jenny Jongstra-Bilen et al.
IMMUNOLOGIC RESEARCH (2006)
Generation and characterization of p38β (MAPK11) gene-targeted mice
VA Beardmore et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression
T Sudo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Small heat shock proteins: molecular structure and chaperone function
Y Sun et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
J Li et al.
CIRCULATION RESEARCH (2005)
Nogo-B is a new physiological substrate for MAPKAP-K2
S Rousseau et al.
BIOCHEMICAL JOURNAL (2005)
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
CE Eyers et al.
BIOCHEMICAL JOURNAL (2005)
Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene
M Fechir et al.
MOLECULAR PHARMACOLOGY (2005)
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
JM Salvador et al.
NATURE IMMUNOLOGY (2005)
The small heat shock protein αB-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3
MC Kamradt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
HDM2 phosphorylation by MAPKAP kinase 2
HO Weber et al.
ONCOGENE (2005)
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation
IA Manke et al.
MOLECULAR CELL (2005)
MK2-induced tristetraprolin: 14-3-3 complexes prevent stress granule association and ARE-mRNA decay
G Stoecklin et al.
EMBO JOURNAL (2004)
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
CA Chrestensen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor α, cyclooxygenase 2, and inflammatory arthritis
K Phillips et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Discovery and characterization of a substrate selective p38α inhibitor
W Davidson et al.
BIOCHEMISTRY (2004)
Catalysis and function of the p38α○MK2a signaling complex
SM Lukas et al.
BIOCHEMISTRY (2004)
Vascular endothelial growth factor: Basic science and clinical progress
N Ferrara
ENDOCRINE REVIEWS (2004)
Cell migration: Rho GTPases lead the way
M Raftopoulou et al.
DEVELOPMENTAL BIOLOGY (2004)
Localized effects of cAMP mediated by distinct routes of protein kinase A
K Tasken et al.
PHYSIOLOGICAL REVIEWS (2004)
Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
H Tran et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Mechanism of p38 MAP kinase activation in vivo
D Brancho et al.
GENES & DEVELOPMENT (2003)
Proteomic identification of 14-3-3ζ as a mitogen-activated protein kinase-activated protein kinase 2 substrate:: Role in dimer formation and ligand binding
DW Powell et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulating mammalian checkpoints through Cdc25 inactivation
M Donzelli et al.
EMBO REPORTS (2003)
Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes
Y Xie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
S Rousseau et al.
EMBO JOURNAL (2002)
Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export
WY Meng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage
LJ Yan et al.
EMBO JOURNAL (2002)
Distinct cellular functions of MK2
A Kotlyarov et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
BX Ge et al.
SCIENCE (2002)
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
A Neininger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities
A Raghavan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure and assembly of a eukaryotic small heat shock protein
RLM van Montfort et al.
NATURE STRUCTURAL BIOLOGY (2001)
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
KR Mahtani et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients
MO Hannigan et al.
JOURNAL OF IMMUNOLOGY (2001)
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
JM Kyriakis et al.
PHYSIOLOGICAL REVIEWS (2001)
Creation of a stress-activated p90 ribosomal S6 kinase - The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function
JK Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
JS Mudgett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Macrophage-induced neutrophil apoptosis
AJ Meszaros et al.
JOURNAL OF IMMUNOLOGY (2000)
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
O Werz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
E Carballo et al.
BLOOD (2000)
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