Journal
MOLECULAR CANCER RESEARCH
Volume 19, Issue 12, Pages 1973-1979Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-21-0411
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Funding
- Department of Defense Award [BGB OC170228, OC200302, OC200225]
- American Cancer Society Research Scholar Award [134106-RSG-19-29-01-DDC]
- NIH/NCI [R37CA261987]
- University of Colorado Cancer Center Support Grant [P30CA046934]
- NIH/NCATS Colorado CTSA [UL1 TR002535]
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The study analyzed the immune cell composition within ovarian cancer tumors and found a correlation between increased presence of B cells and CD4 T cells with overall survival, as well as a significant correlation between the proximity of tumor-associated macrophages and B cells or CD4 T cells with overall survival.
Ovarian cancer is the deadliest gynecologic malignancy. Multi-omics techniques have provided a platform for improved predictive modeling of therapy response and patient outcomes. While high-grade serous carcinoma (HGSOC) tumors are immunogenic and numerous studies have defined positive correlation to immune cell infiltration, immunotherapies in clinical trials have exhibited low efficacy rates. There is a significant need to better comprehend the role and composition of immune cells in mediating ovarian cancer therapeutic response and progression. We performed multiplex IHC with an HGSOC tissue microarray (n = 127) to characterize the immune cell composition within tumors. After analyzing the com-position and spatial context of T cells (CD4/CD8), macrophages (CD68), and B cells (CD19) within the tumor, we found that increased B-cell and CD4 T-cell presence correlated with overall survival. More importantly, we observed that the proximity between tumor-associated macrophages and B cells or CD4 T cells signif-icantly correlated with overall survival.
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