Journal
MOLECULAR CANCER
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12943-021-01431-6
Keywords
Cancer research; CRISPR; Cas9; Gene editing technology; Cancer stem cell; Cancer therapy; Diagnosis of cancer
Categories
Funding
- National Natural Science Foundation of China [82073101, 81872210, 81802948]
- Excellent talent science and technology innovation project of Shanxi Province [201805D211007]
- Shanxi Province Scientific and Technological Achievements Transformation Guidance Foundation [201804D131043]
- Shanxi Province Science Foundation for Excellent Young Scholars [201901D211486]
- Applied Basic Research project of Shanxi province [201801D221421, 201901D211490]
- Shanxi Scholarship Council of China [2020165]
- Fund for the Scientific Activities of Selected Return Overseas Professionals in Shanxi Province [20200034]
- Shenzhen Key Laboratory Foundation [ZDSYS20200811143757022]
- 1111 medical innovation project of Shanxi Province [2020TD26, 2020RC13, 2020RC20]
- Youth Top Talent Program Fund of Shanxi Province
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The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for their development of CRISPR/Cas9 gene editing technology, which has provided new tools for precise gene editing. This technology has been shown to be increasingly used in cancer research and treatment, achieving remarkable results in exploring tumorigenesis and development mechanisms.
The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRISPR/Cas9) gene editing technology that provided new tools for precise gene editing. It is possible to target any genomic locus virtually using only a complex nuclease protein with short RNA as a site-specific endonuclease. Since cancer is caused by genomic changes in tumor cells, CRISPR/Cas9 can be used in the field of cancer research to edit genomes for exploration of the mechanisms of tumorigenesis and development. In recent years, the CRISPR/Cas9 system has been increasingly used in cancer research and treatment and remarkable results have been achieved. In this review, we introduced the mechanism and development of the CRISPR/Cas9-based gene editing system. Furthermore, we summarized current applications of this technique for basic research, diagnosis and therapy of cancer. Moreover, the potential applications of CRISPR/Cas9 in new emerging hotspots of oncology research were discussed, and the challenges and future directions were highlighted.
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