Journal
MOLECULAR BIOTECHNOLOGY
Volume 64, Issue 4, Pages 339-354Publisher
SPRINGERNATURE
DOI: 10.1007/s12033-021-00417-5
Keywords
Coronavirus; COVID-19; Biosensor; Pandemic outbreak; SARS-CoV-1; SARS-CoV-2
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The outbreak of COVID-19 pandemic has caused significant damage to the world, highlighting the urgent need for a quick and easily available biosensor for detection. Research has shown that using real-time RT-PCR assay with molecular beacons can improve the accuracy of detecting SARS-CoV-2 and distinguish between pathogenic and non-pathogenic strains of coronaviruses.
The outbreak of COVID-19 pandemic and its consequences have inflicted a substantial damage on the world. In this study, it was attempted to review the recent coronaviruses appeared among the human being and their epidemic/pandemic spread throughout the world. Currently, there is an inevitable need for the establishment of a quick and easily available biosensor for tracing COVID-19 in all countries. It has been known that the incubation time of COVID-19 lasts about 14 days and 25% of the infected individuals are asymptomatic. To improve the ability to determine SARS-CoV-2 precisely and reduce the risk of eliciting false-negative results produced by mutating nature of coronaviruses, many researchers have established a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay using mismatch-tolerant molecular beacons as multiplex real-time RT-PCR to distinguish between pathogenic and non-pathogenic strains of coronaviruses. The possible mechanisms and pathways for the detection of coronaviruses by biosensors have been reviewed in this study.
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