Journal
MOLECULAR BIOLOGY REPORTS
Volume 49, Issue 1, Pages 567-576Publisher
SPRINGER
DOI: 10.1007/s11033-021-06793-0
Keywords
COVID-19; Corticosteroids; Immunosuppression; Side-effects; Inflammatory-molecules; Cytokine storm
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The use of corticosteroids in COVID-19 patients has sparked controversy and requires further in-depth research to evaluate both its effectiveness and potential side effects.
Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper inflammation, a few physicians and researchers have utilized corticosteroids. Corticosteroid implementation has increased after the publication of interim guidelines regarding corticosteroid use in COVID-19 patients by WHO, despite the remaining controversies regarding long-term side effects and disease progression capability of corticosteroids. In different studies, the implementation of corticosteroids on COVID-19 patients revealed controversial results, which require further intensive research. This review will present the current outcomes and possibilities of using corticosteroids to treat COVID-19 patients.
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