An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field

Cilia are microtubule-based organelles with important functions in motility and sensation. They contribute to a broad spectrum of developmental disorders called ciliopathies and have recently been linked to common conditions such as cancers and congenital heart disease. There has been increasing interest in the biology of cilia and their contribution to disease over the past two decades. In 2013 we published a Gold Standard list of genes confirmed to be associated with cilia. This was published as part of the SYSCILIA consortium for systems biology study dissecting the contribution of cilia to human health and disease, and was named the Syscilia Gold Standard (SCGS). Since this publication, interest in cilia and understanding of their functions have continued to grow, and we now present an updated SCGS version 2. This includes an additional 383 genes, more than doubling the size of SC-GSv1. We use this dataset to conduct a review of advances in understanding of cilia biology 2013-2021 and offer perspectives on the future of cilia research. We hope that this continues to be a useful resource for the cilia community.

Automated summary

Cilia, microtubule-based organelles, play crucial roles in motility and sensation, and are linked to various diseases. Recent years have seen a growing interest in cilia biology and disease research, leading to the discovery of new genes and providing insights for future studies.