Mitophagy in depression: Pathophysiology and treatment targets

Mitochondria, the 'powerhouse' of eukaryotic cells, play a key role in cellular homeostasis. However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell-free mitochondrial DNA (mtDNA) release, leading to increased inflammation. Mitophagy is a vital pathway, which selectively removes defective mitochondria through the process of autophagy. Thus, an impairment in the mitophagy pathway might trigger the gradual accumulation of defective mitochondria. Accumulating evidence suggest that inflammation and mitochondrial dysfunction are linked to the pathogenesis of depression. In this article, we have reviewed the role of impaired mitophagy as a contributing factor in depression pathophysiology. Further, we have discussed the potential therapeutic interventions aimed at modulating mitophagy in depression.

Automated summary

Mitochondria, as the powerhouse of eukaryotic cells, are crucial in the pathogenesis of depression. Impaired mitophagy may lead to increased inflammation and mitochondrial dysfunction in depression patients. Therapeutic interventions targeting modulating mitophagy could potentially be beneficial in treating depression.