Journal
MITOCHONDRION
Volume 62, Issue -, Pages 122-127Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2021.11.005
Keywords
Sleep; Energetics; Mitochondria; Cellular respiration
Categories
Funding
- National Institutes of Health [T32HL082610]
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Poor sleep quality may impair systemic mitochondrial bioenergetics, and in this study, sleep efficiency was found to be positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models, indicating a relationship between sleep and systemic bioenergetic function in humans.
Poor sleep may impair systemic mitochondrial bioenergetics, but this relationship has not been examined in humans. This study examined associations of self-reported sleep with peripheral blood mononuclear cell (PBMC) bioenergetics in adults. Forty-three participants completed the Pittsburgh Sleep Quality Index from which sleep indices were calculated. PBMCs were analyzed for bioenergetics using extracellular flux analysis. Sleep efficiency was positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models. Findings indicate that sleep is related to systemic bioenergetic function in humans.
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