Recent Progress in Andrographolide Derivatization: Structural Modification and Biological Activity

Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

Automated summary

Researchers have prepared numerous bioactive derivatives of andrographolide through chemical modification and classified them according to their biological activities. These studies contribute to the development of novel therapeutic drugs.