Development of locust bean gum and xanthan gum based biodegradable microparticles of celecoxib using a central composite design and its evaluation

Biopolymers are naturally occurring polymeric biomolecules. They are easily accessible, relatively cheap, can be synthetically altered and biodegradable. Locust bean gum and Xanthan gum is widely used ingredient in drug formulations due to their non interacting behavior with the drug and less toxicity. Microparticle formulations of celecoxib, a COX-2 inhibitor were formulated using Locust bean gum and Xanthan gum. Quality by design approach was used and two-factor five level central composite designs were used to perform the experiment. A quadratic polynomial model was produced to anticipate the independent variables with respect to the dependent variable. Studies on formulation variables were done and microparticles were characterized for their size, micrometric properties and surface morphology. In vitro experiments on drug release profile studies have indicated an increase in the drug release retardation with increasing Locust bean gum and Xanthan gum concentration. The microparticles that were formulated were found to be stable with respect to their drug content and physicochemical characters for over a period of 6 months at different temperatures as per the ICH Q1A guidelines. (C) 2015 Elsevier B.V. All rights reserved.