Journal
MICROCHIMICA ACTA
Volume 188, Issue 12, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-021-05084-6
Keywords
Dual catalytic amplification; Molecularly imprinted polymer; Paper chip; Parathion-methyl; Electrochemical impedance spectroscopy
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Funding
- Hainan Provincial Department of Science and Technology, China [ZDYF2020185]
- Central Public-interest Scientific Institution Basal Research Fund for the Chinese Academy of Tropical Agricultural Sciences [1630082020001, 1630082017002, 1251632021005]
- China Agriculture Research System of MOF and MARA [CARS-31]
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A dual catalytic amplification strategy using Fe3O4/C-dots@Ag-MOFs was developed for the detection of PM, achieving high sensitivity and selectivity. The designed electrochemical microfluidic paper-based chip showed a detection limit of 1.16 x 10(-11) mol L-1 and successful application in determining PM in agricultural products and environmental samples. The combination of this strategy with an MIP significantly enhanced the sensitivity and selectivity of the chip.
The rapid detection of insecticides such as parathion-methyl (PM) requires methods with high sensitivities and selectivities. Herein, a dual catalytic amplification strategy was developed using Fe3O4 nanozyme-supported carbon quantum dots and silver terephthalate metal-organic frameworks (Fe3O4/C-dots@Ag-MOFs) as current amplification elements. Based on this strategy, a novel electrochemical microfluidic paper-based chip was designed to detect PM. Fe3O4/C-dots@Ag-MOFs were synthesised by a hydrothermal method, and a molecularly imprinted polymer (MIP) was then synthesised on the surface of Fe3O4/C-dots@Ag-MOFs using PM as a template molecule. Finally, the reaction zone of a chip was modified with MIP/Fe3O4/C-dots@Ag-MOFs. PM from a sample introduced into the reaction zone was captured by the MIP, which generated a reduction current response at - 0.53 V in a three-electrode system embedded in the chip. Simultaneous catalysis by Fe3O4/C-dots and Ag-MOFs significantly enhanced the signal. The chip had a detection limit of 1.16 x 10(-11) mol L-1 and was successfully applied to the determination of PM in agricultural products and environmental samples with recovery rates ranging from 82.7 to 109%, with a relative standard deviation (RSD) of less than 5.0%. This approach of combining a dual catalytic amplification strategy with an MIP significantly increased the sensitivity as well as selectivity of chips and can potentially be used to detect a wide variety of target analytes using microfluidic paper-based chips.
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