Journal
MICROCHIMICA ACTA
Volume 188, Issue 12, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-021-05096-2
Keywords
Glucose determination; Chemiluminescence; Zn-doped zeolitic imidazolate framework-67; Glucose oxidase; Cascade catalytic reaction
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Funding
- Natural Science Foundation of Shaanxi Province [2020JM-035]
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A chemiluminescence sensor was developed for one-step determination of glucose by encapsulating glucose oxidase into Zn-doped zeolitic imidazolate framework-67. The sensor showed linear response and low limit of detection for glucose measurement, with good selectivity and stability in real human serum samples.
A chemiluminescence (CL) sensor was constructed for the one-step determination of glucose. Glucose oxidase (GOx) was successfully encapsulated into Zn-doped zeolitic imidazolate framework-67 (Zn-ZIF-67) via a simple one-pot strategy. The as-prepared GOx@Zn-ZIF-67 nanocomposite can trigger cascade reactions of glucose oxidation to generate H2O2 and H2O2 -mediated luminol reaction to give an intense CL emission. The sensor responds linearly to glucose in the 20.0400.0 mu mol.L-1 range with a limit of detection (LOD) of 4.7 mu mol.L-1. Eleven replicated measurements of 200.0 mu mol.L-1 glucose solution gives a relative standard deviation (RSD) of 1.7%. The sensor exhibits good selectivity and stability and was successfully applied to the determination of glucose in real human serum samples.
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