A novel ion selective electrode based on reduced graphene oxide for potentiometric determination of sarafloxacin hydrochloride

In this study, a novel potential sensor based on electrochemical co-reduction of graphene oxide (r-GO) was developed to detect sarafloxacin hydrochloride (SARA) by the potential response value. Fourier infrared spectroscopy (FI-IR), atomic force microscopy (AFM), X-ray diffraction (XRD), scanning electron microscope (SEM), and differential thermal analysis (DTA) were used to characterize the prepared electro-active substance (SARATPB) and modifier for the modification of platinum electrodes. The different assembly steps of the sensor were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Compared with traditional electrodes under optimized conditions, the improved electrode had a wider linear range (1.0 x 10(-2) to 1.0 x 10(-7) mol/L) and the limit of detection (LOD) was 5.51 x 10 (-8) mol/L (based on S/N = 3), and the equilibration time was shorter (20 s). In addition, the sensor exhibited good selectivity, repeatability (RSD less than 5%), stability, and a wide pH range (3.3-7.0) in the detection of actual samples.

Automated summary

A novel potential sensor based on electrochemical co-reduction of graphene oxide was developed for detecting sarafloxacin hydrochloride by potential response value. The improved electrode showed wider linear range, lower limit of detection, and shorter equilibration time, while exhibiting good performance in the detection of actual samples.