Journal
MICROBIAL PATHOGENESIS
Volume 162, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2021.105212
Keywords
Lactobacillus fermentum; Complete genome; Genetic; Probiotics
Categories
Funding
- China Agriculture Research System of MOF
- MARA [XZ2019ZRG-94]
- Natural Science Foundation of Tibet Autonomous Region [CARS-37]
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This study analyzed the probiotic characteristics and potential probiotic ability of L. fermentum YLF016. The strain exhibited high survival rate, antibacterial activity, antioxidant activity, and strong adherence to intestinal cells, indicating its potential as a probiotic.
Lactobacillus fermentum (L. fermentum) YLF016 is a well-characterized probiotic with several favorable characteristics. This study aimed to analyze the probiotic characteristics of L. fermentum and uncover the genes implicated in its potential probiotic ability on the base of its genomics features. The complete genome of L. fermentum YLF016 was found to have a circular chromosome of 2,094,354 bp, and 51.46% G + C content without any plasmid. Its chromosome contained 2,130 predicted protein-encoding genes, 58 tRNA, and 15 rRNAencoding genes. Also, it was found to have many other probiotic properties, such as a high survival rate in the gastrointestinal tract with strong adherence to intestinal cells, antibacterial activity against pathogens, and antioxidant activity. Moreover, the genome sequence analysis demonstrated specific genes coding for carbon metabolism pathway, genetic adaption, stress resistance, and adhesive ability. Further analysis revealed its non hemolytic activity and its non-functional ability of virulence factors. In conclusion, L. fermentum YLF016 possesses many valuable probiotic properties that refer to its potential probiotic ability.
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