Journal
METABOLIC ENGINEERING
Volume 71, Issue -, Pages 62-76Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2022.02.001
Keywords
Anaerobic digestion; Biogas; Metabolic pathways; Microbial communities; Syntrophic relation
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Funding
- SERB-Department of Science and Technology, Ministry of Science and Technology Government of India [ECR/2016/000989]
- Department of Biotechnology, Ministry of Science and Technology for Ramalingaswami Re-Entry fellowship Government of India [BT/RLF/Reentry/04/2013]
- Department of Bio-technology (DBT), India [BT/IN/BMBF-Germany/29/SKM/2016-17]
- Federal Ministry of Education and Research (BMBF), Germany [BT/IN/BMBF-Germany/29/SKM/2016-17]
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This review explores the metabolic bottlenecks of microbial communities and their optimization methods using the latest analytical approaches. It also investigates the microbial interactions in consortia and the effects of external factors on metabolic pathways.
Anaerobic digestion is a promising method for energy recovery through conversion of organic waste to biogas and other industrial valuables. However, to tap the full potential of anaerobic digestion, deciphering the microbial metabolic pathway activities and their underlying bioenergetics is required. In addition, the behavior of organisms in consortia along with the analytical abilities to kinetically measure their metabolic interactions will allow rational optimization of the process. This review aims to explore the metabolic bottlenecks of the microbial communities adopting latest advances of profiling and C-13 tracer-based analysis using state of the art analytical platforms (GC, GC-MS, LC-MS, NMR). The review summarizes the phases of anaerobic digestion, the role of microbial communities, key process parameters of significance, syntrophic microbial interactions and the bottlenecks that are critical for optimal bioenergetics and enhanced production of valuables. Considerations into the designing of efficient synthetic microbial communities as well as the latest advances in capturing their metabolic cross talk will be highlighted. The review further explores how the presence of additives and inhibiting factors affect the metabolic pathways. The critical insight into the reaction mechanism covered in this review may be helpful to optimize and upgrade the anaerobic digestion system.
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