Journal
MEDICINAL RESEARCH REVIEWS
Volume 42, Issue 3, Pages 1147-1178Publisher
WILEY
DOI: 10.1002/med.21873
Keywords
andrographolide; drug delivery system; inflammatory diseases; pharmacodynamics; pharmacokinetics
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Funding
- National Natural Science Foundation of China [91853109, 81730100, 81872877, 81673436]
- Zhejiang University special scientific research fund for COVID-19 prevention and control [2020XGZX007, 2020XGZX027]
- Mountain-Climbing Talents Project of Nanjing University
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Andrographolide, a natural lactone with a range of pharmacological actions in traditional Chinese medicine, shows promising potential in treating inflammatory diseases and cancers. Its effects have been studied extensively in preclinical use and clinical trials, highlighting advancements in both disease categories.
Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric, breast, prostate, lung, and oral cancers has also been reviewed. In addition, several clinical trials of andrographolide in inflammatory diseases and cancers have been summarized. This review highlights recent advances in ameliorating inflammatory diseases as well as cancers by andrographolide and its analogs, providing a new perspective for subsequent research of this traditional natural product.
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