4.2 Article

High chromosomal mobility of rDNA clusters in holocentric chromosomes of Triatominae, vectors of Chagas disease (Hemiptera-Reduviidae)

Journal

MEDICAL AND VETERINARY ENTOMOLOGY
Volume 36, Issue 1, Pages 66-80

Publisher

WILEY
DOI: 10.1111/mve.12552

Keywords

Chagas disease vectors; FISH; Hemiptera; holocentric chromosomes; rDNA clusters; Triatominae

Funding

  1. 'Comision Sectorial de Investigacion Cientifica' (CSIC-Udelar) [160]
  2. 'Ministerio de Educacion y Cultura, Direccion Nacional de Innovacion, Ciencia y Tecnologia, Fondo Vaz Ferreira' [II/FVF/2019/054]
  3. 'Programa de Desarrollo de las Ciencias Basicas' (PEDECIBA)
  4. 'Agencia Nacional de Investigacion e Innovacion' (ANII) from Uruguay
  5. Program of Academic Mobility of AUIP (Ibero-American University Postgraduate Association: AUIP) from Spain
  6. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/05015-7, 19/02145-2]
  7. CNPq from Brazil [PQ-2, 307 398/2018-8]
  8. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/05015-7] Funding Source: FAPESP

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The subfamily Triatominae, which includes more than 150 blood-sucking species, has stable chromosome numbers. Research has shown that the mobility of rDNA clusters has been common in the evolutionary history of this group, potentially affecting genetic recombination and species diversification.
The subfamily Triatominae (Hemiptera-Reduviidae) includes more than 150 blood-sucking species, potential vectors of the protozoan Trypanosoma cruzi, causative agent of Chagas disease. A distinctive cytogenetic characteristic of this group is the presence of extremely stable chromosome numbers. Unexpectedly, the analyses of the chromosomal location of ribosomal gene clusters and other repetitive sequences place Triatominae as a significantly diverse hemipteran subfamily. Here, we advance the understanding of Triatominae chromosomal evolution through the analysis of the 45S rDNA cluster chromosomal location in 92 Triatominae species. We found the 45S rDNA clusters in one to four loci per haploid genome with different chromosomal patterns: On one or two autosomes, on one, two or three sex chromosomes, on the X chromosome plus one to three autosomes. The movement of 45S rDNA clusters is discussed in an evolutionary context. Our results illustrate that rDNA mobility has been relatively common in the past and in recent evolutionary history of the group. The high frequency of rDNA patterns involving autosomes and sex chromosomes among closely related species could affect genetic recombination and the viability of hybrid populations, which suggests that the mobility of rDNA clusters could be a driver of species diversification.

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