Journal
MEDIATORS OF INFLAMMATION
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/2689600
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Funding
- National Natural Science Foundation of China [81974569]
- China Postdoctoral Science Foundation [2018M640345]
- Key Program of Anhui University Natural Science Research [KJ2018A0277]
- National Natural Science Foundation of China, Joint Fund for Regional Innovation and Development [U20A20398]
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This review explores the mechanisms of circadian clock and autophagic imbalance in COPD, as well as the connection between the two, providing further theoretical basis for the study on the pathogenesis of COPD.
Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation. It is documented that oscillation and dysregulated expression of circadian clock genes, like Bmal1, Per1, and Per2, involved in COPD pathogenies, including chronic inflammation and imbalanced autophagy level, and targeting the associations of circadian rhythm and autophagy is promising strategies in the management and treatment of COPD. Herein, we reviewed the mechanisms of the circadian clock and the unbalance of the autophagic level in COPD, as well as the link between the two, so as to provide further theoretical bases for the study on the pathogenesis of COPD.
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