Related references
Note: Only part of the references are listed.Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Paul D. Robbins et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Raffaella Di Micco et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)
Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells
Dawei Yang et al.
LIFE SCIENCES (2021)
Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9
Hui Li et al.
ARCHIVES OF TOXICOLOGY (2020)
Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII
Yongjian Guo et al.
FREE RADICAL BIOLOGY AND MEDICINE (2020)
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Yonghan He et al.
AGING CELL (2020)
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
Chi Zhang et al.
AGING-US (2020)
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
George M. Burslem et al.
CELL (2020)
Discovery, development, and future application of senolytics: theories and predictions
Erin O. Wissler Gerdes et al.
FEBS JOURNAL (2020)
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
Estela Gonzalez-Gualda et al.
AGING CELL (2020)
Galactose-modified duocarmycin prodrugs as senolytics
Ana Guerrero et al.
AGING CELL (2020)
Identification of SYK inhibitor, R406 as a novel senolytic agent
Hyun-Ji Cho et al.
AGING-US (2020)
Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Yusheng Cai et al.
CELL RESEARCH (2020)
Reducing Senescent Cell Burden in Aging and Disease
Robert J. Pignolo et al.
TRENDS IN MOLECULAR MEDICINE (2020)
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Yonghan He et al.
NATURE COMMUNICATIONS (2020)
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Masahiro Wakita et al.
NATURE COMMUNICATIONS (2020)
Role of p53 in the Regulation of Cellular Senescence
Mahmut Mijit et al.
BIOMOLECULES (2020)
Preclinical antitumor efficacy of senescence -inducing chemotherapy combined with a nanoSenolytic
Irene Galiana et al.
JOURNAL OF CONTROLLED RELEASE (2020)
Senolytic CAR T cells reverse senescence-associated pathologies
Corina Amor et al.
NATURE (2020)
A Senescence-Centric View of Aging Implications for Longevity and Disease
M. Borghesan et al.
TRENDS IN CELL BIOLOGY (2020)
Recent update on discovery and development of Hsp90 inhibitors as senolytic agents
Sayan Dutta Gupta et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)
Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
Hosni Cherif et al.
ELIFE (2020)
The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals
Yejin Zhu et al.
MOLECULES (2020)
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
Sona Hubackova et al.
CELL DEATH AND DIFFERENTIATION (2019)
The Role of Curcumin in the Modulation of Ageing
Anna Bielak-Zmijewska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro
Hosni Cherif et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
James Chapman et al.
FEBS LETTERS (2019)
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
Hubert Fleury et al.
NATURE COMMUNICATIONS (2019)
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Uxia Nogueira-Recalde et al.
EBIOMEDICINE (2019)
Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer
Sayan Dutta Gupta et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP
Wang Peilin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Identification and characterization of Cardiac Glycosides as senolytic compounds
Francisco Triana-Martinez et al.
NATURE COMMUNICATIONS (2019)
The curcumin analog EF24 is a novel senolytic agent
Wen Li et al.
AGING-US (2019)
Cardiac glycosides are broad-spectrum senolytics
Ana Guerrero et al.
NATURE METABOLISM (2019)
Oxidation resistance 1 is a novel senolytic target
Xin Zhang et al.
AGING CELL (2018)
A review on the chemotherapeutic potential of fisetin: In vitro evidences
Kiruthika Sundarraj et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
Xingui Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
A versatile drug delivery system targeting senescent cells
Daniel Munoz-Espin et al.
EMBO MOLECULAR MEDICINE (2018)
Senotherapeutics for healthy ageing
Laura J. Niedernhofer et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Two-Step Senescence-Focused Cancer Therapies
Cynthia J. Sieben et al.
TRENDS IN CELL BIOLOGY (2018)
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al.
EBIOMEDICINE (2018)
Azithromycin and Roxithromycin define a new family of senolytic drugs that target senescent human fibroblasts
Bela Ozsvari et al.
AGING-US (2018)
Induced protein degradation: an emerging drug discovery paradigm
Ashton C. Lai et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Ok Hee Jeon et al.
NATURE MEDICINE (2017)
Senescent cells: an emerging target for diseases of ageing
Bennett G. Childs et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg et al.
NATURE COMMUNICATIONS (2017)
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer
Liqin Wang et al.
CELL REPORTS (2017)
Cellular Senescence: A Translational Perspective
James L. Kirkland et al.
EBIOMEDICINE (2017)
A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC
Leleesha Samaraweera et al.
SCIENTIFIC REPORTS (2017)
Senescence in Health and Disease
Shenghui He et al.
CELL (2017)
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Marjolein P. Baar et al.
CELL (2017)
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Yi Zhu et al.
AGING-US (2017)
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Jianhui Chang et al.
NATURE MEDICINE (2016)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Yi Zhu et al.
AGING CELL (2016)
Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Yingying Wang et al.
AGING-US (2016)
D-Peptides as Recognition Molecules and Therapeutic Agents
Min Liu et al.
CHEMICAL RECORD (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Reut Yosef et al.
NATURE COMMUNICATIONS (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
Monitoring Lipid Peroxidation within Foam Cells by Lysosome-Targetable and Ratiometric Probe
Xinfu Zhang et al.
ANALYTICAL CHEMISTRY (2015)
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Bennett G. Childs et al.
NATURE MEDICINE (2015)
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Joel D. Leverson et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Geroscience: Linking Aging to Chronic Disease
Brian K. Kennedy et al.
CELL (2014)
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria et al.
DEVELOPMENTAL CELL (2014)
Cellular senescence: from physiology to pathology
Daniel Munoz-Espin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Fisetin: A Dietary Antioxidant for Health Promotion
Naghma Khan et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J. Souers et al.
NATURE MEDICINE (2013)
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
Binh Vu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Delphine Merino et al.
BLOOD (2012)
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
Karen Barnett et al.
LANCET (2012)
Aging with multimorbidity: A systematic review of the literature
Alessandra Marengoni et al.
AGEING RESEARCH REVIEWS (2011)
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
Simone M. Schoenwaelder et al.
BLOOD (2011)
Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9
Liwen Li et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells
Liwen Li et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Mikko Taipale et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
Christin Tse et al.
CANCER RESEARCH (2008)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
MY Li et al.
NATURE (2002)
Share Paper
