4.6 Article

Control of COVID-19 outbreak using an extended SEIR model

Journal

MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES
Volume 31, Issue 12, Pages 2399-2424

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0218202521500512

Keywords

COVID-19; SARS-CoV-2; SEIR compartmental models; non-pharmaceutical intervention; optimal control; data-fitting; New Jersey

Funding

  1. NSF CMMI project [2033580]
  2. Cornell University
  3. Vanderbilt University
  4. Joseph and Loretta Lopez Chair endowment

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This paper aims to predict the situation of COVID-19 in New Jersey using a SEIR model and proposes a more refined model, which includes measures such as social distancing, testing, contact tracing and quarantining, to minimize the economic cost of the pandemic. The proposed model allows for finding optimal strategies by implementing various non-pharmaceutical interventions and studying different scenarios and likely initial conditions.
The outbreak of COVID-19 resulted in high death tolls all over the world. The aim of this paper is to show how a simple SEIR model was used to make quick predictions for New Jersey in early March 2020 and call for action based on data from China and Italy. A more refined model, which accounts for social distancing, testing, contact tracing and quarantining, is then proposed to identify containment measures to minimize the economic cost of the pandemic. The latter is obtained taking into account all the involved costs including reduced economic activities due to lockdown and quarantining as well as the cost for hospitalization and deaths. The proposed model allows one to find optimal strategies as combinations of implementing various non-pharmaceutical interventions and study different scenarios and likely initial conditions.

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