Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 129, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112395
Keywords
Polydopamine; Graphene oxide; Antibacterial properties; Adhesion; NIR driven shrinkage
Categories
Funding
- Natural Science Foundation of China [81571829]
- Natural Science Foundation of Gansu Province [20JR10RA597]
- Fundamental Research Funds for the Central Universities [lzujbky-2020-it29, lzujbky-2021-ct08]
- Open Project of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences [LSL-1907]
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A novel hydrogel composed of PDA, Ag and GO was fabricated for wound dressing via the chemical crosslinking of NIPAM and BIS, showing effective antibacterial properties and high adhesion ability. Under NIR irradiation, the hydrogel can produce strong contractility to accelerate wound healing, achieving a 100% wound healing rate within 15 days.
The lacks of antibacterial properties, low adhesion and delayed wound healing of the hydrogel wound dressings limit their applications in wound treatment. To resolve these, a novel hydrogel composed of polydopamine (PDA), Ag and graphene oxide (GO) is fabricated for wound dressing via the chemical crosslinking of N-isopropylacrylamide (NIPAM) and N,N'-methylene bisacrylamide (BIS). The prepared hydrogel containing PDA@Ag(5)GO(1) (Ag(5)GO(1) denotes the mass ratio between Ag and GO is 5:1) exhibits effective antibacterial properties and high inhibition rate against E. coli and S. aureus. It shows high adhesion ability to various substrate materials, implying a simpler method to the wound obtained by self-fixing rather than suturing. More important, it can produce strong contractility under the irradiation of near-infrared light (NIR), exerting a centripetal force that helps accelerate wound healing. Thus, the hydrogel containing a high concentration PDA@Ag(5)GO(1) irradiated by NIR can completely repair the wound defect (1.0 x 1.0 cm(2)) within 15 days, the wound healing rate can reach 100%, which was far higher than other groups. Taken together, the new hydrogel with excellent antibacterial, high adhesion and strong contractility will subvert the traditional treatment methods on wound defect, extending its new application range in wound dressing.
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